Results 161 to 170 of about 525,103 (266)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

The "respiratory envelope", an aviation-inspired framework for patient tailored mechanical ventilation. [PDF]

Crit Care
Meuwese CL, Oppersma E, Somhorst P, Heunks L, Melkert JA, Jonkman AH.   +5 more
europepmc   +1 more source

Controlling Photochromism of Donor‐Acceptor Stenhouse Adducts on Micro‐Dot Arrays Beyond Human‐Eyes Resolution for Dynamic Light Encryption

Advanced Science, EarlyView.
This study presents a micro‐dot array strategy for dynamic light encryption, utilizing DASA‐based photochromism with resolution beyond human‐eye capacity. By precisely controlling isomerization kinetics, the method reveals multi‐layered encrypted information under specific light irradiation, enhancing information security and anti‐counterfeiting ...
Hongtao Hu, Fanxi Sun, Hanjun Zhang, Xiao Wang, Gaolu Zhu, Jiayu Li, Mengyao Yang, Xu Deng, Yonghao Zheng, Chen Wei, Dongsheng Wang   +10 more
wiley   +1 more source

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis. [PDF]

mBio
Carr JF, Basurto De Santiago C, Bhut SA, Warzecha DJ, Vastani SA, Wei R, Herrera CM, Trent MS, Nan B, Mitchell AM.   +9 more
europepmc   +1 more source

Interfacial Polysulfide Confinement via Spatially Controlled Sulfonated Metal–Organic Polyhedra Coatings in Lithium–Sulfur Batteries

Advanced Science, EarlyView.
Spatially controlled sulfonated metal–organic polyhedra (SMOP) coating on sulfur‐loaded hollow carbon spheres form ultrathin, conformal interfacial barriers that selectively confine soluble polysulfides, stabilize sulfur redox, and suppress shuttle reactions.
Soyeon Ko, WooYeon Moon, Yuwei Zhu, Yuhui An, Yunyuan Lu, Sourayan Bal, Linqin Mu, Kyung Min Choi, Yoon Hwa   +8 more
wiley   +1 more source

A Radar-Based Contactless System for Joint Phonocardiogram Reconstruction and Cardiac State Segmentation Using a Self-Attention 1D U-Net. [PDF]

Sensors (Basel)
Montanari G, Mura M, Di Viesti P, Vignoli E, Guerzoni G, Vitetta GM.   +5 more
europepmc   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Gram-negative-staining Bacillaceae with thick cell wall and monoderm architecture uncover evolutionary diversity and challenge Gram-based classification. [PDF]

Commun Biol
García-Miranda N, Cantellano ME, Hernández-Tamayo R, Delaye L, Olmedo-Álvarez G.   +4 more
europepmc   +1 more source

Physics‐Constrained Constitutive Learning of Rate‐Limiting Timescales for Efficient Hydrogen‐Based Direct Reduction for Green Steel Making

Advanced Science, EarlyView.
A conversion‐resolved constitutive framework is developed for the hydrogen‐based direct reduction of iron oxide pellets. Effective reaction and transport timescales are inferred directly from measured trajectories and mapped against operating conditions, pellet architecture, and composition. The analysis reveals how late‐stage transport control emerges
Anurag Bajpai, Barak Ratzker, Pasquale Cavaliere, Dierk Raabe   +3 more
wiley   +1 more source

A Multi-Channel AM-TMAS Driving System Based on Amplitude-Modulated Sine Waves. [PDF]

Bioengineering (Basel)
Shi Y, Li Z, Liu R, Zhang X, Wang M, Ma R, Yin T, Zhou X, Liu Z.   +8 more
europepmc   +1 more source