Results 41 to 50 of about 525,103 (266)
Molecular OncologyPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a 5‐year survival rate of 7.2% in China. However, effective approaches for diagnosis of PDAC are limited.
Guochao Zhao +16 more
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Multitasking: Making the Most out of the Retroviral Envelope
Viruses, 2010 Evasion of the host’s immune system is a required step for the establishment of viral infection. In this article, we discuss the recent findings of Heidmann and colleagues demonstrating that some retroviruses possess an immune suppressive (IS) domain ...
Mariana Varela, Massimo Palmarini
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The Interplay between HIV-1 Gag Binding to the Plasma Membrane and Env Incorporation
Viruses, 2020 Advancement in drug therapies and patient care have drastically improved the mortality rates of HIV-1 infected individuals. Many of these therapies were developed or improved upon by using structure-based techniques, which underscore the importance of ...
R. Elliot Murphy, Jamil S. Saad
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Visualizing the Integrity of Chloroplast Envelope by Rhodamine and Nile Red Staining
Frontiers in Plant Science, 2021 Chloroplasts are essential organelles in plant cells with many important functions. Chloroplasts isolated by Percoll density gradient centrifugation are widely used in the study of chloroplasts.
Jinjie An +11 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The HIV Env Glycoprotein Conformational States on Cells and Viruses
mBio, 2022 The HIV Env glycoprotein is the surface glycoprotein responsible for viral entry into CD4+ immune cells. During infection, Env also serves as a primary target for antibody responses, which are robust but unable to control virus replication.
Connie Zhao +3 more
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Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
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eLife, 2017 Primates have co-opted a viral gene to produce an envelope protein that prevents infection by the HERV-T virus and likely contributed to the extinction of this virus.
Julia H Wildschutte, John M Coffin
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Research on Envelope Profile of Lithium Niobate on Insulator Stepped-Mode Spot Size Converter
MicromachinesTo enhance the end-face coupling efficiency of lithium niobate on insulator (LNOI) chips, in conjunction with current device fabrication processes, a stepped spot size converter (SSC) based on a special outer envelope profile has been proposed and ...
Jianfeng Bao +4 more
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