New insights into epileptic spasm generation and treatment from the TTX animal model
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann +2 more
wiley +1 more source
Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1. [PDF]
Kaewjiw N +13 more
europepmc +1 more source
Unveiling the chemical and biological properties of Litsea cubeba essential oil. ABSTRACT Litsea cubeba essential oil (LCEO) is recognised for its broad spectrum of biological activities, including antimicrobial and insecticidal effects, making it a promising natural alternative to synthetic agents.
Miroslava Kačániová +10 more
wiley +1 more source
Correction to: Elevated serum mtDNA in COVID‑19 patients is linked to SARS‑CoV‑2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release. [PDF]
Shteinfer-Kuzmine A +9 more
europepmc +1 more source
The HBV large envelope protein initiates virion assembly by recruiting capsids at membrane rich domains related to late endosome. [PDF]
Seigneuret F +9 more
europepmc +1 more source
Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia. [PDF]
Zhang J +11 more
europepmc +1 more source
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui +9 more
wiley +1 more source
Curcuminoids amplify host innate antiviral immunity via the CRYAB‐RBM26 axis in viral infection
DMC/CUR antagonize viral hijacking of host nucleic acid resources and finely regulate the induction and effector phases of the type I interferon (IFN‐I) pathway through the CRYAB‐RBM26 axis. This molecular axis serves as a key downstream regulator for DMC/CUR activation of the IFN‐I pathway.
Tingting Chen +18 more
wiley +1 more source

