Results 221 to 230 of about 4,160,774 (255)

A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity. [PDF]

Nat Commun
Bibby S, Jung J, Low YS, Amarilla AA, Newton ND, Scott CAP, Balk J, Ting YT, Freney ME, Liang B, Grant T, Coulibaly F, Young P, Hall RA, Hobson-Peters J, Modhiran N, Watterson D.   +16 more
europepmc   +1 more source

GH172 Difructose Dianhydride I Synthase: A Two‐Stepped Journey via Glycosylation and Cyclization Using QM/MM Metadynamics

Chemistry – A European Journal, EarlyView.
Unlocking the chemistry of caramel by simulations and experimental validation. αFFase1${\alpha }\rm{FFase1}$ converts inulobiose into difructose dianhydride I, one component of caramel, through two steps: a rate‐limiting glycosylation (with a rare sugar ring flip) followed by a cyclization step, guided by residues E85, K147, and N226.
Santiago Alonso‐Gil, Bruno Di Geronimo, Toma Kashima, Akihiro Ishiwata, Katsunori Tanaka, Kiyotaka Fujita, Shinya Fushinobu, Pedro A. Sánchez‐Murcia   +7 more
wiley   +1 more source

Photostability of Cyanine Dyes and Its Correlation to Their Photothermal and Photodynamic Effects

Chemistry – A European Journal, EarlyView.
Photostability (PS) of dyes is a crucial parameter for performance in biological applications, yet often underrated. Here PS of several cyanines is investigated. The method is carefully evaluated and designed as a general and easy tool to compare PS of NIR dyes.
Clara Schäfer, Bo W. Laursen
wiley   +1 more source

ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates. [PDF]

NPJ Vaccines
Shrivastava S, Carmen JM, Kim J, Peachman KK, Basu S, Alving R, Nettere D, Kundu G, Yum L, Rahman MA, Jha S, Trinh HV, Rosado L, Nguyen P, Morrison E, Swafford I, Machmach K, Bolton JS, Yates A, Misicka E, Beck Z, Mutascio S, Jobe O, Zemil McCrea M, Wieczorek L, Bergmann-Leitner ES, Polonis V, Paquin-Proulx D, Pollara J, Matyas GR, Alving CR, Thomas R, Franchini G, Ferrari G, Haynes BF, Ake JA, Rao M.   +36 more
europepmc   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source

Evaluation of Potential Inhibitors of Zika Virus Envelope Protein Through Molecular Docking and Molecular Dynamics Simulation. [PDF]

Virus Res
Tayyeb JZ, da Silva MK, Al-Mutairi AA, Alharbi HM, Khojah AA, Bayıl I, Alzahrani AYA, Tóth Z, Oliveira JIN, Zaki MEA.   +9 more
europepmc   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Expression of HIV envelope protein in the human central nervous system. [PDF]

AIDS
Agbey C, Walton S, Campbell LA, Nath A, Smith B, Snow J, Wiebold A, Hou C, Ma J, Mocchetti I, and the NIH-Neuro-HIV Research Consortium.   +10 more
europepmc   +1 more source

The EMA Qualification Opinion for CYP Inhibition‐Mediated Drug–Drug Interaction Predictions: Implications for PBPK Credibility Assessment in the Era of ICH M15

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical pharmacology and pharmacometrics teams are now being encouraged to implement the ICH M15 framework in drug development to support model‐informed decisions in regulatory submissions. Although model performance is an important component of model evaluation, regulatory confidence also depends on the intended context of use (CoU) and the ...
Karen Rowland Yeo, Sibylle Neuhoff, Oliver Hatley, Iain Gardner, Céline Brochot, Frédéric Y. Bois, Masoud Jamei   +6 more
wiley   +1 more source

Multivalent display of envelope protein domain III with Mi3 nanoparticles induces protective immunity against lethal Zika virus infection in mice. [PDF]

Virol Sin
Sun X, Jiang H, Yu W, Wang N, Li Z, Lu J, Xie X, Feng L.   +7 more
europepmc   +1 more source