Results 61 to 70 of about 521,167 (261)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Interference of the Zika Virus E-Protein With the Membrane Attack Complex of the Complement System

Frontiers in Immunology, 2020
The complement system has developed different strategies to clear infections by several effector mechanisms, such as opsonization, which supports phagocytosis, attracting immune cells by C3 and C5 cleavage products, or direct killing of pathogens by the ...
Zahra Malekshahi, Britta Schiela, Sarah Bernklau, Zoltan Banki, Reinhard Würzner, Heribert Stoiber   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Recombinant expression and immunogenicity verification of Dabie bandavirus proteins Gn and Gc

Frontiers in Microbiology
IntroductionDabie bandavirus (DBV), a newly identified pathogen transmitted to humans via ticks bites, is the etiologic agent of severe fever with thrombocytopenia syndrome (SFTS).
Xiuyu Lou, Haiyan Mao, Yihan Lou, Yi Sun, Feng Wang, Minjie Wang, Lijun Zhang, Zhihan Fang, Hao Yan, Huijun Zhang   +9 more
doaj   +1 more source

Genome sequence of canine herpesvirus [PDF]

, 2016
Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United ...
Davison, Andrew, Graham, Elizabeth M., McDonald, Michael, Papageorgiou, Konstantinos V., Suárez, Nicolás M., Wilkie, Gavin S.   +5 more
core   +2 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Immunization With Fc-Based Recombinant Epstein–Barr Virus gp350 Elicits Potent Neutralizing Humoral Immune Response in a BALB/c Mice Model

Frontiers in Immunology, 2018
Epstein–Barr virus (EBV) was the first human virus proved to be closely associated with tumor development, such as lymphoma, nasopharyngeal carcinoma, and EBV-associated gastric carcinoma. Despite many efforts to develop prophylactic vaccines against EBV
Bingchun Zhao, Xiao Zhang, Claude Krummenacher, Claude Krummenacher, Shuo Song, Shuo Song, Ling Gao, Haojiong Zhang, Miao Xu, Lin Feng, Qisheng Feng, Musheng Zeng, Yuting Xu, Yixin Zeng   +13 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A morphological view on mitochondrial protein targeting [PDF]

, 1994
Mitochondrial protein targeting includes both intramitochondrial sorting of proteins encoded by the organellar genome and import and subsequent sorting of nuclear encoded precursor proteins. Only a few proteins are encoded by the mitochondrial genome and
Ades, Allmann, Ardail, Ardail, Ardail, Attardi, Baker, Biermans, Biermans, Brdiczka, Brdiczka, Eilers, Glick, Hackenbrock, Hackenbrock, Hackenbrock, Hartl, Hartl, Hines, Hwang, Kellems, Kiebler, Knoll, Lill, Lithgow, Malhotra, Martin, Marzuki, McEnery, Murakami, Nicolay, Ohlendieck, Pain, Pfanner, Pfanner, Pfanner, Pon, Rassow, Rassow, Rassow, Rojo, Schleyer, Schwaiger, Stuart, Suissa, Söllner, Söllner, Söllner, van Venetië, Vestweber, Vestweber, Vignais, Watson, Werner, Wienhues, Zara   +55 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source