Results 121 to 130 of about 1,993,735 (313)

PROBLEM ISSUES OF ACCOUNTING AND VALUATION OF ENVIRONMENTAL DAMAGE

Вестник университета, 2019
The article discusses the role of accounting information, the basic organizational and functional issues accounting and valuation of environmental damage with the implementation of the principle of payment for the exploitation of the natural wealth of ...
T. Rogulenko
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

ANÁLISIS DOGMÁTICO DEL DERECHO PENAL AMBIENTAL CHILENO, A LA LUZ DEL DERECHO COMPARADO Y LAS OBLIGACIONES CONTRAÍDAS POR CHILE EN EL ÁMBITO DEL DERECHO INTERNACIONAL: CONCLUSIONES Y PROPUESTA LEGISLATIVA FUNDADA PARA UNA NUEVA PROTECCIÓN PENAL DEL MEDIO AMBIENTE EN CHILE

Ius et Praxis, 2003
El presente artículo corresponde al Informe Final del Proyecto FONDECYT 1010206­2001, sobre tratamiento penal de los delitos contra el medio ambiente en Chile.
Jean Pierre Matus Acuña, Marcos Orellana Cruz, Marcelo Castillo Sánchez, M Cecilia Ramírez Guzmán   +3 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Allocating environmental costs among heterogeneous sources: The linear damage equivalent mechanism. [PDF]

A group of firms has to divide the costs associated with environmental damages jointly generated as a by-product of their heterogeneous production activities.
Arguedas, Carmen, Kranich, Laurence
core  

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Optimal valve location in long oil pipelines [PDF]

We address the valve location problem, one of the basic problems in design of long oil pipelines. Whenever a pipeline is depressurized, the shutoff valves block the oil flow and seal the damaged part of the pipeline.
Grigoriev, A., Grigorieva, N.V.
core   +1 more source

A study of the effects of ground cover on overwintering slug populations and effect of coulter design on slug incidence in direct drilling : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science at Massey University [PDF]

, 1982
A two stage study involving the effect of vegetation cover on overwintering slug populations, and the effect of coulter design on slug incidence and damage in a direct drilled cereal was carried out during the 1980/81 growring season.
Follas, George Brian
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Ecocide: from a war crime to an international crime?

Opolskie Studia Administracyjno-Prawne
in response to the relevance achieved in the last decade, this article explores the evolution of ecocide as a legal concept, from its origins to its contemporary status as a potential international crime, with the aim of assessing whether current ...
Jonatan Rigo-García
doaj   +1 more source