Results 121 to 130 of about 1,410,058 (263)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

ANÁLISIS DOGMÁTICO DEL DERECHO PENAL AMBIENTAL CHILENO, A LA LUZ DEL DERECHO COMPARADO Y LAS OBLIGACIONES CONTRAÍDAS POR CHILE EN EL ÁMBITO DEL DERECHO INTERNACIONAL: CONCLUSIONES Y PROPUESTA LEGISLATIVA FUNDADA PARA UNA NUEVA PROTECCIÓN PENAL DEL MEDIO AMBIENTE EN CHILE

Ius et Praxis, 2003
El presente artículo corresponde al Informe Final del Proyecto FONDECYT 1010206­2001, sobre tratamiento penal de los delitos contra el medio ambiente en Chile.
Jean Pierre Matus Acuña, Marcos Orellana Cruz, Marcelo Castillo Sánchez, M Cecilia Ramírez Guzmán   +3 more
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Ecocide: from a war crime to an international crime?

Opolskie Studia Administracyjno-Prawne
in response to the relevance achieved in the last decade, this article explores the evolution of ecocide as a legal concept, from its origins to its contemporary status as a potential international crime, with the aim of assessing whether current ...
Jonatan Rigo-García
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Allocating environmental costs among heterogeneous sources: The linear damage equivalent mechanism. [PDF]

A group of firms has to divide the costs associated with environmental damages jointly generated as a by-product of their heterogeneous production activities.
Arguedas, Carmen, Kranich, Laurence
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Role of Local Communities in Managing Environmental Damage to Address Social Conflicts

Journal of Natural Resources and Environmental Management
Environmental damage from palm oil production remains a pressing and significant global issue, driving ecosystem disruption and social conflicts. Local communities, as the first to experience its impacts, are central actors in addressing deforestation ...
Herdis Herdiansyah, Mustarini Dessy Vitiara, Evi Frimawaty   +2 more
doaj   +1 more source

MACROECONMIC TENDENCIES OF ENVIRONMENTAL TAXES IN [PDF]

Reforms of environmental taxes in EU member states began to consolidate a strategic conceptual basis since the early '90s, when it was launched the idea of changing the tax burden from the tax factor of production, work to the environmental factors and ...
Cristea Anca
core