Results 61 to 70 of about 518,567 (266)

Our research progress in heteroaggregation and homoaggregation of organic π‐conjugated systems

Aggregate, 2021
Construction of crystalline homo/heteroaggregation at micro/nanometer level from organic π‐conjugated systems is of great importance because the controllable morphologies (i.e., size, shape, and dimension) could provide diverse optoelectronic properties ...
Xin Deng, Xiaohui Yu, Jinchong Xiao, Qichun Zhang   +3 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Melanogenesis and MITF expression in primary melanomas: an immunohistochemical study

Surgical and Experimental Pathology
Background The Microphthalmia-associated transcription factor - MITF is a key regulator of melanogenesis, controlling melanin production and pigment phenotype in melanocytes. It also influences cell differentiation, proliferation, and survival.
Karina Munhoz de Paula Alves Coelho, Jaqueline Stall, Rodrigo Blasius, Bruna Louise Silva, Hercílio Fronza Junior, Paulo Henrique Condeixa de França   +5 more
doaj   +1 more source

New Advances in Bioelectrochemical Systems in the Degradation of Polycyclic Aromatic Hydrocarbons: Source, Degradation Pathway, and Microbial Community

Energies
Because of their high persistence, polycyclic aromatic hydrocarbons (PAHs) are found in a wide range of settings and pose a health risk to both humans and other organisms. Degradation of PAHs is an essential part of environmental management. By combining
Yimeng Feng, Xuya Zhu, Xiulin Huang, Fengxiang Li   +3 more
doaj   +1 more source

Potencial Geoparque de Uberaba (MG): geodiversidade e geoconservação / Geopark potential of Uberaba (MG): geodiversity and geoconservation [PDF]

Sociedade & Natureza, 2013
Uberaba municipality, Western Minas Gerais State, has a great geotouristic potential, regarding itsgeological heritage. The igneous rocks from Serra Geral Formation are found in 12 points, highlightingPonte Alta (40 meters) and Peirópolis III (7 meters ...
Fabiano Tomazini da Conceição, Reinaldo José Bertini, Diego de Souza Sardinha, Letícia Hirata Godoy, Carolina Del Roveri, César Augusto Moreira   +5 more
doaj  

Chlorophyll Fluorescence Imaging for Environmental Stress Diagnosis in Crops

Sensors
The field of plant phenotype is used to analyze the shape and physiological characteristics of crops in multiple dimensions. Imaging, using non-destructive optical characteristics of plants, analyzes growth characteristics through spectral data. Among these, fluorescence imaging technology is a method of evaluating the physiological characteristics of ...
Beomjin Park, Seunghwan Wi, Hwanjo Chung, Hoonsoo Lee   +3 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source