Results 31 to 40 of about 799,848 (265)

Mitogenomic Insights into Orthocladiinae (Diptera: Chironomidae): Structural Diversity and Phylogenetic Implications

open access: yesBiology
Mitochondrial genomes are powerful tools for taxonomic delimitation and species identification, yet they remain scarce for Chironomidae (Diptera). In this study, we assembled and annotated 63 new mitochondrial genomes, encompassing 63 species within 39 ...
Hai-Feng Xu   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Data Structure-Aware Ensemble Modeling for Time-Series Prediction: A Case Study of Sewage Generation

open access: yesApplied Sciences
This study investigates the influence of time-series data structure on model behavior in sewage generation estimation. Annual data from four regions (2017–2023) were analyzed using Random Forest (RF) and Voting Regressor (VR), while structural ...
Jae-Sang Lee   +4 more
doaj   +1 more source

Preliminary survey of Aphanomyces sp. associated with native and invasive crayfish in the Lower Susquehanna watershed of South Central Pennsylvania

open access: yesJournal of Freshwater Ecology, 2020
The oomycete species, Aphanomyces astaci, is well known as the devastating causal agent of European crayfish plague. Despite assumptions of a North American origin, the prevalence and distribution of A. astaci in its presumed native range is unknown.
Elizabeth Butler   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Species Delimitation and Cryptic Diversity in Rheotanytarsus Thienemann & Bause, 1913 (Diptera: Chironomidae) Based on DNA Barcoding

open access: yesInsects
The genus Rheotanytarsus Thienemann & Bause, 1913 (Diptera: Chironomidae) currently includes more than 120 recognized species worldwide, but precise species-level identification based solely on morphology remains challenging.
Yuan Yao   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genetic Reference Gaps Limit eDNA Metabarcoding and Biodiversity Monitoring of Tropical Mangrove Ecosystems

open access: yesEnvironmental DNA
Mangroves support high faunal diversity and provide essential ecological services. However, biodiversity assessments in these habitats remain constrained by their structural complexity, resulting in limited accessibility, low visibility, and persistent ...
Earl Kevin T. Cooper   +14 more
doaj   +1 more source

Comparative Mitogenomic Analyses of Psectrocladius (Diptera: Chironomidae)

open access: yesInsects
Psectrocladius, a genus within the species-rich subfamily Orthocladiinae (Diptera: Chironomidae), remains poorly resolved in molecular phylogenetics due to limited available molecular data. Here, we sequenced and analyzed the complete mitogenomes of five
Xue-Yao Chen   +6 more
doaj   +1 more source

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