Results 51 to 60 of about 6,899,226 (260)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Desiccation to DNA: Bulk DNA Metabarcoding of Macroinvertebrate Egg Banks via Sugar‐Flotation Enhances Biodiversity Surveys of Dry Salt Lakes

Ecology and Evolution
Ephemerally inundated salt lakes in arid regions support unique aquatic macroinvertebrate communities that typically persist through dry periods as resistant resting‐stages (e.g., spores, eggs).
Angus D'Arcy Lawrie, Pia Dethlefsen, Mahabubur Rahman, Christopher Hofmeester, Jessica Delaney, Matthew A. Campbell, Joshua P. Newton, Marina Elisa deOliveira, Joel Huey, Morten E. Allentoft, Mattia Saccò   +10 more
doaj   +1 more source

Comparative Mitogenomic Analyses of Tanypodinae (Diptera: Chironomidae)

Insects
Tanypodinae, a highly diverse subfamily within Chironomidae (Diptera), has been poorly represented in mitochondrial genome (mitogenome) databases, with only a limited number of complete or partial sequences available.
Xiu-Ru Xiao, Meng-Han Chen, Shu-Yi Li, Bing-Xin Guo, Yan Zhang, Zhi-Chao Zhang, Ya-Jun Qiao, Xiao-Long Lin   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Is There a Causal Association between Genotoxicity and the Imposex Effect? [PDF]

, 2005
There is a growing body of evidence that indicates common environmental pollutants are capable of disrupting reproductive and developmental processes by interfering with the actions of endogenous hormones.
Depledge, Michael H., Hagger, Josephine A., Michael H. Depledge, Susan Jobling, Jobling, S, Jobling, Susan, Galloway, Tamara S., Oehlmann, Jörg, Oehlmann, J, Tamara S. Galloway, Hagger, JA, Josephine A. Hagger, Jörg Oehlmann, Depledge, MH, Galloway, TS   +14 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Comparative Analysis of Environmental DNA Metabarcoding and Spectro-Fluorescence for Phytoplankton Community Assessments [Elektronisk resurs]

Quantifications of phytoplankton biomass and species composition are crucial for monitoring biodiversity and population dynamics in aquatic environments, and both direct microscopic counts and fluorescence-based methods have been widely used for ...
Hansson, Lars-Anders, Salis, Romana, Hansson, Lars Anders, Salis, Romana K.,, Salis, Romana K., Hansson, Lars-Anders,   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Guide to Environmental DNA Extractions for Non‐Molecular Trained Biologists, Ecologists, and Conservation Scientists

Ecologists, biologists, and conservation scientists are increasingly interested in the use of environmental DNA (eDNA) data for research and potentially decision‐making.
Adrian-Kalchhauser, Irene, Jemmi, Eliane Inessa, Rieder, Jessica Marie, Hunter, Margaret E.   +3 more
core   +1 more source