Results 81 to 90 of about 2,730,918 (321)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Electric bus system with rapid charging at every bus stop using renewable energy

open access: yesMechanical Engineering Journal, 2014
In order to prevent global warming, the emissions of greenhouse gases must be reduced. In public transportation systems, electric buses can help to achieve this.
Takeshi KAWASHIMA
doaj   +1 more source

Environmental urbanization assessment using gis and multicriteria decision analysis: a case study for Denizli (Turkey) municipal area [PDF]

open access: yes, 2018
In recent years, life quality of the urban areas is a growing interest of civil engineering. Environmental quality is essential to display the position of sustainable development and asserts the corresponding countermeasures to the protection of ...
Akyol, Erdal   +4 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Study of the Use of Gas Diffusion Anode with Various Cathodes (Cu-Ag, Ni-Co, and Cu-B Alloys) in a Microbial Fuel Cell

open access: yesEnergies
Advancing microbial fuel cell (MFC) technologies appears to be a crucial direction in bolstering wastewater treatment efforts. It ensures both energy recovery (bioelectricity production) and wastewater pre-treatment. One of the problems in the widespread
Paweł P. Włodarczyk   +1 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Analysis of Greenhouse Gas Emission Load and Emission Reduction from Switching to Electric Vehicles: A Case Study of Java Island

open access: yesJurnal Presipitasi
In order to  mitigate the impact of climate change  arising from Greenhouse Gas (GHG) emissions generated from the transportation sector, many countries  including Indonesia, have  initiated to develop policies to encourage environmentally friendly ...
Surya Adi Wicaksono   +3 more
doaj   +1 more source

FESTivE: an information system method to improve product designers and environmental experts information exchanges [PDF]

open access: yes, 2014
Effective collaboration between product designers and environmental experts is an important driver for the ecodesign practice in industry. This paper investigates the principal functions required for such an e ective collaboration and aims at ...
REYES, Tatiana   +2 more
core   +5 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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