Results 81 to 90 of about 4,948,801 (399)

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Environmental Enrichment Protects Against Sepsis-Associated Encephalopathy-Induced Learning and Memory Deficits by Enhancing the Synthesis and Release of Vasopressin in the Supraoptic Nucleus

Journal of Inflammation Research, 2022
Shan Jiang,1,* Yong-Qiang Wang,2,* Yifei Tang,1 Xi Lu,1 Dan Guo1 1Department of Rehabilitation Medicine, the China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China; 2Department of Ophthalmology, the Sunshine Union Hospital ...
Jiang S, Wang YQ, Tang Y, Lu X, Guo D
doaj  

Environmental enrichment and the sensory brain: the role of enrichment in remediating brain injury

Frontiers in Systems Neuroscience, 2014
The brain’s life-long capacity for experience-dependent plasticity allows adaptation to new environments or to changes in the environment, and to changes in internal brain states such as occurs in brain damage.
Dasuni Sathsara Alwis, Ramesh eRajan
doaj   +1 more source

Long-term environmental enrichment affects microglial morphology in middle age mice

Aging, 2019
Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related ...
Seemaab Ali, Xianglan Liu, N. Queen, Ripal Patel, Ryan K. Wilkins, X. Mo, Lei Cao   +6 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Distribution and origin of lead in stream sediments from small agricultural catchments draining Miocene molassic deposits (SW France) [PDF]

, 2009
Total Pb concentrations and isotopic composition were determined in stream-bed sediments and bedrock from 29 small agricultural or forested catchments in the Gascogne area (SW France). The contribution of Pb from various natural and anthropogenic sources
Bur, Thomas, N'Guessan, Yao Mathieu, Probst, Anne, Probst, Jean-Luc   +3 more
core   +2 more sources

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Environmental Enrichment for Broiler Breeders: An Undeveloped Field

Frontiers in Veterinary Science, 2017
Welfare problems, such as hunger, frustration, aggression, and abnormal sexual behavior, are commonly found in broiler breeder production. To prevent or reduce these welfare problems, it has been suggested to provide stimulating enriched environments. We
Anja B. Riber, Ingrid C. de Jong, Heleen A. van de Weerd, Sanna Steenfeldt   +3 more
doaj   +1 more source

Deformable Object Tracking with Gated Fusion [PDF]

IEEE Transactions on Image Processing, 2019, 2018
The tracking-by-detection framework receives growing attentions through the integration with the Convolutional Neural Networks (CNNs). Existing tracking-by-detection based methods, however, fail to track objects with severe appearance variations. This is because the traditional convolutional operation is performed on fixed grids, and thus may not be ...
arxiv   +1 more source

Have we reproduced Rat Park? Conceptual but not direct replication of the protective effects of social and environmental enrichment in addiction [PDF]

, 2020
The Rat Park studies are classic experiments in addiction neuroscience, yet they have not been successfully replicated directly and several serious methodological criticisms have been raised.
Khoo, Shaun Yon-Seng
core   +1 more source