Results 51 to 60 of about 5,390,472 (369)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

open access: yesFEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker   +8 more
wiley   +1 more source

An Investigation of Obligatory Anthropoholism as Plausible African Environmental Ethics [PDF]

open access: yes, 2019
African ontological discourse revolves around a few principles, the interrelatedness of being, what is variously interpreted as communalism, ubuntu, Holism, communitarianism etc.
Ifeakor, Chinedu S.
core  

A Post-environmental Ethics?

open access: yesEthics, Place & Environment, 2003
This essay offers a critique of environmental ethics and argues that a post-environmental ethics may be unavoidable. It does so by exposing and questioning the ontological assumptions common to otherwise different modalities of environmental ethics. These modalities, it is argued, rest upon an implicit or explicit 'material essentialism'.
openaire   +6 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

open access: yesFEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri   +5 more
wiley   +1 more source

Book review essay: Perspectives on environmental ethics [PDF]

open access: yes, 2009
Most introductory texts in environmental ethics (and philosophy in general) are anthologies, and there are advantages to this approach. No philosopher is an expert on all aspects of the field, especially if practical concerns such as climate change ...
Gunn, Alastair S.
core   +1 more source

Development Ethics [PDF]

open access: yes, 2016
A 4,000 word overview of the field of development ethics, with special reference to the interface with environmental ethics. The essay outlines characteristic concerns of development ethics, with special attention to issues around the recognition of ...
Gasper, D.R. (Des)
core   +2 more sources

A Brief History of Enviroethics and Its Challenges [PDF]

open access: yesJournal of Medical Ethics and History of Medicine, 2009
Environmental ethics has emerged during the early 1970s, when environmentalists started urging philosophers to consider the philosophical aspects of environmental problems. Environmental ethics considers the ethical relationships between humanity and non-
Marjan Laal
doaj   +2 more sources

Human Rights and Environmental Ethics [PDF]

open access: yesحقوق بشر, 2010
Happiness of human beings in his/her worldly life and even the hereafter has direct contact with the environment’s health. Healthy environment is central to the worldly and spiritual human prosperity.
Mohammad Ali Basir, Davood Najafi
doaj  

Energy Equality and the Challenges of Population Growth

open access: yesRelations, 2018
This paper points out the relation between population growth and energy justice in a finite world. Reflecting on the meaning of limits, I propose to look at energy justice in a broader sense: restoring a safe and more equal operating space for humanity ...
Andrea Natan Feltrin
doaj   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

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