Results 51 to 60 of about 1,384,930 (310)

Wild Emptiness: A Zen Approach to Environmental Ethics [PDF]

open access: yes, 2019
When Buddhism took root in China and integrated with the nation’s Taoist intellectual climate, the tradition retained the orthodox central objective of overcoming suffering.
Porter, Arden D
core   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

How Big Data Analytics Capability Promotes Green Radical Innovation? The Effect of Corporate Environment Ethics in Digital Era

open access: yesSystems
In the digital economy era, firms pursue innovation while also considering their environmental impact to ensure alignment with sustainability. However, existing research offers limited insights into how corporate environmental ethics influence the ...
Weiwei Wu, Xue Li, Guowei Ruan
doaj   +1 more source

Nature-Based Tourism Businesses in Colorado: Interpreting Environmental Ethics and Responsible Behavior [PDF]

open access: yes, 2011
Tourism businesses operate from a primarily economic-centric point of view, but nature-based tourism businesses are also acutely aware of the need to sustain the natural resource that attracts the client to their outdoor recreation service. A preliminary
Gaede, Diane   +2 more
core   +3 more sources

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla   +15 more
wiley   +1 more source

Ecocinema, Slow Violence, and Environmental Ethics:

open access: yesCrossings, 2021
In the Anthropocene epoch, slow violence triggered by human-caused environmental disaster is omnipresent across the globe. By forming an alternative media-spectatorship/readership in a media-saturated, fast-changing world, ecocinema can potentially help
Shibaji Mridha
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

The aesthetic turn in green marketing: Environmental consumer ethics of natural personal care products [PDF]

open access: yes, 2004
Green consumerism is on the rise in America, but its environmental effects are contested. Does green marketing contribute to the greening of American consciousness, or does it encourage corporate greenwashing? This tenuous ethical position means that eco-
Todd, Anne Marie
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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