Results 61 to 70 of about 4,397,150 (323)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Investigation of Pre-service Teachers' Environmental Ethics Awareness and Attitudes towards Sustainable Environment

open access: yesAnadolu Üniversitesi Eğitim Fakültesi dergisi
The aim of this study was to determine the environmental ethics awareness and sustainable environmental attitudes of pre-service teachers to reveal the teachers’ access to the content specified in undergraduate education.
Birsen Berfu Akaydın, Aslı Eşme
doaj   +1 more source

PEMANTAPAN DIMENSI ETIKA DAN ASAS SEBAGAI PENGUATAN SISTEM HUKUM LINGKUNGAN DI INDONESIA

open access: yesAudito Comparative Law Journal, 2021
Humans as social beings who use the environment make the law an instrument of regulation and protection. Laws relating to the environment itself systemically provide both general and specific regulation.
Himas Muhammady Imammullah El Hakim
doaj   +1 more source

African Environmental Ethics

open access: yesThe International Library of Environmental, Agricultural and Food Ethics, 2019
For decades now, experts have studied and documented the severe environmental and land degradation across Africa. However, the nature of the problem has now been ratcheted up by mounting and undisputed scientific evidence demonstrating a clear causal ...
J. Ogar, S. A. Bassey
semanticscholar   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Ecocinema, Slow Violence, and Environmental Ethics:

open access: yesCrossings, 2021
In the Anthropocene epoch, slow violence triggered by human-caused environmental disaster is omnipresent across the globe. By forming an alternative media-spectatorship/readership in a media-saturated, fast-changing world, ecocinema can potentially help
Shibaji Mridha
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Environmental Ethics

open access: yesDictionary of Geotourism, 2019
Environmental ethics is an area that investigates the question of which ethical norms are appropriate for governing human interactions with the natural environment. Considered a branch of applied or practical ethics, environmental ethics has only existed
Mfonobong David Udoudom   +3 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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