Why environmental exposures? [PDF]
Concerns about environmental health are rising. Publics, scientists and policymakers have grown increasingly alarmed about adverse health effects arising from catastrophic accidents such as the Bho...
Kelly Joyce, Laura Senier
openaire +2 more sources
Exposure Prioritization (Ex Priori): A Screening-Level High-Throughput Chemical Prioritization Tool
To estimate potential chemical risk, tools are needed to prioritize potential exposures for chemicals with minimal data. Consumer product exposures are a key pathway, and variability in consumer use patterns is an important factor. We designed Ex Priori,
Heidi F. Hubbard+6 more
doaj +1 more source
A Scalar-on-Quantile-Function Approach for Estimating Short-term Health Effects of Environmental Exposures [PDF]
Environmental epidemiologic studies routinely utilize aggregate health outcomes to estimate effects of short-term (e.g., daily) exposures that are available at increasingly fine spatial resolutions. However, areal averages are typically used to derive population-level exposure, which cannot capture the spatial variation and individual heterogeneity in ...
arxiv
Estimation and false discovery control for the analysis of environmental mixtures [PDF]
The analysis of environmental mixtures is of growing importance in environmental epidemiology, and one of the key goals in such analyses is to identify exposures and their interactions that are associated with adverse health outcomes. Typical approaches utilize flexible regression models combined with variable selection to identify important exposures ...
arxiv
ML4EJ: Decoding the Role of Urban Features in Shaping Environmental Injustice Using Interpretable Machine Learning [PDF]
Understanding the key factors shaping environmental hazard exposures and their associated environmental injustice issues is vital for formulating equitable policy measures. Traditional perspectives on environmental injustice have primarily focused on the socioeconomic dimensions, often overlooking the influence of heterogeneous urban characteristics ...
arxiv
Human Mobility Disproportionately Extends PM2.5 Emission Exposure for Low Income Populations [PDF]
Ambient exposure to fine particulate matters of diameters smaller than 2.5{\mu}m (PM2.5) has been identified as one critical cause for respiratory disease. Disparities in exposure to PM2.5 among income groups at individual residences are known to exist and are easy to calculate.
arxiv
Kernel Machine and Distributed Lag Models for Assessing Windows of Susceptibility to Environmental Mixtures in Children's Health Studies [PDF]
Exposures to environmental chemicals during gestation can alter health status later in life. Most studies of maternal exposure to chemicals during pregnancy have focused on a single chemical exposure observed at high temporal resolution. Recent research has turned to focus on exposure to mixtures of multiple chemicals, generally observed at a single ...
arxiv +1 more source
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali+3 more
wiley +1 more source
Environmental exposures in utero and microRNA
Understanding the effects of in-utero exposures to environmental agents is of great importance as the resulting deregulation of biological processes can affect both fetal development and health outcomes that manifest later in life. Due to their established role in developmental processes and inherent stability ex vivo, microRNAs (miRNAs) have emerged ...
Maya Kappil, Jia Chen
openaire +4 more sources
Background When suspended in cell culture medium, nano-objects composed of soluble metals such as silver can dissolve resulting in ion formation, altered particle properties (e.g. mass, morphology, etc.), and modulated cellular dose.
Jordan N. Smith+9 more
doaj +1 more source