Results 81 to 90 of about 820,093 (273)
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Environmental xenobiotic exposure and autoimmunity [PDF]
Current Opinion in Toxicology, 2018 Susceptibility to autoimmune diseases is dependent on multigenic inheritance, environmental factors, and stochastic events. Although there has been substantial progress in identifying predisposing genetic variants, a significant challenge facing autoimmune disease research is the identification of the specific events that trigger loss of tolerance ...
Dwight H. Kono +3 more
openaire +3 more sources
The effect of noise on the predictive limit of QSAR models
Journal of Cheminformatics, 2021 A key challenge in the field of Quantitative Structure Activity Relationships (QSAR) is how to effectively treat experimental error in the training and evaluation of computational models.
Scott S. Kolmar, Christopher M. Grulke
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Environmental epigenetics in metal exposure [PDF]
Epigenetics, 2011 Although it is widely accepted that chronic exposure to arsenite, nickel, chromium and cadmium increases cancer incidence in individuals, the molecular mechanisms underlying their ability to transform cells remain largely unknown. Carcinogenic metals are typically weak mutagens, suggesting that genetic-based mechanisms may not be primarily responsible ...
Ricardo Martinez-Zamudio, Hyo Chol Ha
openaire +3 more sources
Enhanced representation of soil NO emissions in the Community Multiscale Air Quality (CMAQ) model version 5.0.2 [PDF]
Geoscientific Model Development, 2016 Modeling of soil nitric oxide (NO) emissions is highly uncertain and may misrepresent its spatial and temporal distribution. This study builds upon a recently introduced parameterization to improve the timing and spatial distribution of soil NO emission ...
Q. Z. Rasool +6 more
doaj +1 more source
Visualizing Environmental Justice Issues in Urban Areas with a Community-based Approach [PDF]
Spatial Data Science Symposium 2021, 2021 According to environmental justice, environmental degradation and benefits should not be disproportionately shared between communities. Identifying disparities in the spatial distribution of environmental degradation is therefore a prerequisite for validating the state of environmental justice in a geographic region.
arxiv
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Estimating the health effects of environmental mixtures using Bayesian semiparametric regression and sparsity inducing priors [PDF]
arXiv, 2017 Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification of health effects associated with environmental mixtures a critical goal for establishing environmental policy sufficiently protective of human health.
arxiv