Results 91 to 100 of about 5,640,250 (316)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mono-(2-ethylhexyl) phthalate impairs insulin secretion in rat insulinoma cells by inducing ferroptosis via oxidative stress

open access: yesEcotoxicology and Environmental Safety
Di(2-ethylhexyl) phthalate (DEHP), a frequently used plasticizer, is a prototypical endocrine-disrupting chemical. The mechanism by which DEHP affects glucose regulation and insulin resistance has not been fully elucidated. Mono-(2-ethylhexyl) phthalate (
Ruichen Lei   +6 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

open access: yesFEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Hydrological factors influencing sediment concentration fluctuations in small drainage basins [PDF]

open access: yes, 1971
Although sediment concentrations measured in two contrasting streams in East Yorkshire fluctuate in response to similar hydrological factors, the effectiveness of these factors reflects the environmental characteristics of the drainage basins ...
Imeson, A.C.
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Temporal-spatial distribution characteristics and associated socioeconomic factors of visiting frequency for rural patients with hypertension in Fujian Province, Southeast China

open access: yesBMC Public Health
Background Regular follow-up and medication can effectively reduce the risk of adverse outcomes for patients with hypertension. This study aimed to explore the temporal-spatial distribution characteristics and associated socioeconomic factors of visiting
Rong Fu   +5 more
doaj   +1 more source

Using GLOBE Data to Analyze Land Cover [PDF]

open access: yes, 2003
The purpose of the resource is to develop hypotheses about which environmental factors are most important to plants.
The GLOBE Program, University Corporation for Atmospheric Research (UCAR)
core  

The gut microbiota, environmental factors, and links to the development of food allergy [PDF]

open access: gold, 2020
Khui Hung Lee   +4 more
openalex   +1 more source

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