Results 71 to 80 of about 19,657,865 (308)

Association of prenatal parabens exposure with adverse pregnancy outcomes: the role of prenatal depressive symptoms

Frontiers in Public Health
BackgroundParabens (PBs) are common endocrine-disrupting preservatives linked to adverse pregnancy outcomes, while prenatal depressive symptoms are also prevalent and harmful. Their combined effects remain poorly understood.ObjectiveTo examine individual
Mengjun Chang, Mengjun Chang, Xianjia Li, Xianjia Li, Ye Li, Ye Li, Yueyi Lv, Yueyi Lv, Jin Ji, Jin Ji, Can Liu, Can Liu, Yunyun Du, Yunyun Du, Shuqin Ma, Suzhen Guan, Suzhen Guan   +16 more
doaj   +1 more source

The Hippo signaling pathway contributes to the 2,5-Hexadion-induced apoptosis of ovarian granulosa cells

Journal of Ovarian Research, 2023
Although n-hexane can induce ovarian damage by inducing ovarian granulosa cell (GC) apoptosis, the mechanism underlying this induction of apoptosis has not been fully elucidated.
Yi Sun, Huiting Chen, Sichuan Chen, Xueming Xu, Wenchang Zhang, Yuchen Li   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

Translational Neurodegeneration, 2019
Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB).
S. Pang, P. Ho, Huifang Liu, Chi-Ting Leung, Lingfei Li, E. Chang, D. Ramsden, S. Ho   +7 more
semanticscholar   +1 more source

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effects of di(2-ethylhexyl) phthalate on glucose homeostasis in rats due to impaired autophagy flux of islet β cells mediated by oxidative stress

环境与职业医学
BackgroundDi(2-ethylhexyl) phthalate (DEHP) is the most prevalent environmental endocrine disruptor among phthalate acid esters (PAEs) worldwide. Previous studies have indicated that exposure to DEHP may disrupt glucose metabolism.ObjectiveTo investigate
Hongyang ZHOU, Yuting HU, Xue CHEN, Yunqiang ZHOU, Liping LI, Ling LI, Herong LIU   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Environmental factors shaping the gut microbiome in a Dutch population

Nature, 2022
R. Gacesa, A. Kurilshikov, A. Vich Vila, T. Sinha, M. Klaassen, L. Bolte, S. Andreu-Sánchez, L. Chen, V. Collij, S. Hu, J. Dekens, V. Lenters, J. Björk, J. C. Swarte, M. Swertz, B. Jansen, J. Gelderloos-Arends, S. Jankipersadsing, M. Hofker, R. Vermeulen, S. Sanna, H. Harmsen, C. Wijmenga, J. Fu, A. Zhernakova, R. Weersma   +25 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source