Results 91 to 100 of about 13,240,040 (288)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Prenatal paraben exposure and pregnancy complications: The moderating role of psychological anxiety

Ecotoxicology and Environmental Safety
Objective: This study aimed to investigate the individual and combined effects of prenatal parabens (PBs) exposure on pregnancy complications and to determine whether pregnancy-related anxiety modifies these associations.
Xianjia Li, Mengjun Chang, Rui Zhang, Yueyi Lv, Jin Ji, Ye Li, Can Liu, Yunyun Du, Xi Shi, Shuqin Ma, Suzhen Guan   +10 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mono-(2-ethylhexyl) phthalate impairs insulin secretion in rat insulinoma cells by inducing ferroptosis via oxidative stress

Ecotoxicology and Environmental Safety
Di(2-ethylhexyl) phthalate (DEHP), a frequently used plasticizer, is a prototypical endocrine-disrupting chemical. The mechanism by which DEHP affects glucose regulation and insulin resistance has not been fully elucidated. Mono-(2-ethylhexyl) phthalate (
Ruichen Lei, Yuting Hu, Xue Chen, Hongyang Zhou, Yunqiang Zhou, Yuhong Zhang, Liping Li   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Donkey milk-induced PPARα activation enhances lipid metabolism and ameliorates renal fibrosis in CKD rats

Journal of Functional Foods
Background: Chronic kidney disease (CKD) is characterized by renal injury often accompanied by inflammation, oxidative stress, and disordered lipid metabolism. Donkey milk contains nutritional components making it suitable for patients with CKD. However,
Chen Man, Cui Huimin, Lu Tenyu, Hao Wenhao, Chen Zihan, Gong Wei, Yang Jianjun   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Temporal-spatial distribution characteristics and associated socioeconomic factors of visiting frequency for rural patients with hypertension in Fujian Province, Southeast China

BMC Public Health
Background Regular follow-up and medication can effectively reduce the risk of adverse outcomes for patients with hypertension. This study aimed to explore the temporal-spatial distribution characteristics and associated socioeconomic factors of visiting
Rong Fu, Zhi Huang, Yulan Lin, Xuwei Tang, Zhenquan Zheng, Zhijian Hu   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source