Results 81 to 90 of about 13,802,604 (294)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Associations of eHealth literacy and dietary diversity with depressive symptoms among patients with chronic diseases in rural Western China

Frontiers in Digital Health
ObjectiveThe global prevalence of depressive symptoms has been increasing steadily. Both eHealth literacy and dietary diversity are closely linked to mental health.
Yanan Chen, Yanan Chen, Ting Zhao, Ting Zhao, Chunsheng Li, Chunsheng Li, Haodong Meng, Haodong Meng, Hui Qiao, Hui Qiao   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mono-(2-ethylhexyl) phthalate impairs insulin secretion in rat insulinoma cells by inducing ferroptosis via oxidative stress

Ecotoxicology and Environmental Safety
Di(2-ethylhexyl) phthalate (DEHP), a frequently used plasticizer, is a prototypical endocrine-disrupting chemical. The mechanism by which DEHP affects glucose regulation and insulin resistance has not been fully elucidated. Mono-(2-ethylhexyl) phthalate (
Ruichen Lei, Yuting Hu, Xue Chen, Hongyang Zhou, Yunqiang Zhou, Yuhong Zhang, Liping Li   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prenatal paraben exposure and pregnancy complications: The moderating role of psychological anxiety

Ecotoxicology and Environmental Safety
Objective: This study aimed to investigate the individual and combined effects of prenatal parabens (PBs) exposure on pregnancy complications and to determine whether pregnancy-related anxiety modifies these associations.
Xianjia Li, Mengjun Chang, Rui Zhang, Yueyi Lv, Jin Ji, Ye Li, Can Liu, Yunyun Du, Xi Shi, Shuqin Ma, Suzhen Guan   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Ohio Environmental Education Fund State Fiscal Year 2021 agenda

, 2020
"March 2020."Grant programs -- Environmental science and engineering career initiatives -- Water quality education and monitoring by students and citizens -- ContactThis fact sheet summarizes the SFY21 annual plan of the office of Environmental Education
Ohio EPA. Office of Environmental Education
core