Results 61 to 70 of about 5,718,297 (303)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Analysis of health risk factors for older adults living alone in China and establishment and evaluation of a nomogram prediction model

Frontiers in Public Health
ObjectiveTo understand the health status of older adults living alone in China and analyze the influencing factors, so as to provide reference for improving the health status of older adults living alone.MethodsBased on CGSS data from China General ...
Kexin Chen, Kexin Chen, Jiangwei Qiu, Jiangwei Qiu, Wenlong Wang, Wenlong Wang, Qi Hu, Qi Hu, Hui Qiao, Hui Qiao   +9 more
doaj   +1 more source

Some Observations on the Role of Water States for Biological and Therapeutical Effects

Innovative Biosystems and Bioengineering, 2018
The peculiar properties of water are recalled, among them the “memory of water”, underlining the behavior of cell water, whose “ordered” structure is probably due to the endogenous electromagnetic fields generated by organelles inside the cells, such ...
Massimo Scalia, Pasquale Avino, Massimo Sperini, Valentina Viccaro, Albina Pisani, Vincenzo I. Valenzi   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Housing conditions, cooking fuels, and health-related quality of life among rural middle-aged and elderly in northwest China: A ten-year balanced panel study

Preventive Medicine Reports
Objective: To investigate the impacts of improving housing conditions and transitioning to clean cooking fuels on health-related quality of life (HRQOL) among middle-aged and elderly populations in rural China.
Kexin Chen, Wenlong Wang, Jiangwei Qiu, Wenqin Guo, Jiancai Du, Baokai Gao, Zhaoyan Hu, Hui Qiao   +7 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A prognostic index for non-smoking and non-drinking female patients with oral cancer in Fujian province

Zhongguo gonggong weisheng, 2022
Objective To explore prognostic risk factors and develop a prognostic index (PI) for non-smoking, non-drinking females (NSNDF) with oral cancer in Fujian province, and to provide evidences for prognosis prediction and individualized treatment of NSNDF ...
Zhao-jun TANG, Zhao-cheng ZHUANG, Shi-ting YANG   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Association of internet use and health service utilization with self-rated health in middle-aged and older adults: findings from a nationally representative longitudinal survey

Frontiers in Public Health
ObjectiveThis study aims to explore the relationship between internet use and self-rated health among middle-aged and older adults and further investigates the mediating role of health service utilization between internet use and self-rated health ...
Ximin Ma, Ximin Ma, Qi Hu, Qi Hu, Jiahui He, Jiahui He, Wenlong Wang, Wenlong Wang, Kexin Chen, Kexin Chen, Hui Qiao, Hui Qiao   +11 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source