Results 51 to 60 of about 16,763,210 (296)

Moving in the Dark: Enlightening the Spatial Population Ecology of European Cave Salamanders

Population Ecology, EarlyView.
We assessed individual interactions, movement ecology and activity patterns of a subterranean population of Speleomantes strinatii, applying spatial capture–recapture modeling to a photographic dataset of 104 individuals. ABSTRACT Space use and movement are fundamental aspects of organisms' ecology, mirroring individual fitness, behavior, and life ...
Giacomo Rosa, Andrea Costa, Sebastiano Salvidio   +2 more
wiley   +1 more source

Association of internet use and health service utilization with self-rated health in middle-aged and older adults: findings from a nationally representative longitudinal survey

Frontiers in Public Health
ObjectiveThis study aims to explore the relationship between internet use and self-rated health among middle-aged and older adults and further investigates the mediating role of health service utilization between internet use and self-rated health ...
Ximin Ma, Ximin Ma, Qi Hu, Qi Hu, Jiahui He, Jiahui He, Wenlong Wang, Wenlong Wang, Kexin Chen, Kexin Chen, Hui Qiao, Hui Qiao   +11 more
doaj   +1 more source

Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort.

JAMA psychiatry, 2019
Importance The origins and development of autism spectrum disorder (ASD) remain unresolved. No individual-level study has provided estimates of additive genetic, maternal, and environmental effects in ASD across several countries. Objective To estimate
Dan Bai, B. Yip, G. Windham, A. Sourander, R. Francis, R. Yoffe, E. Glasson, B. Mahjani, Auli Suominen, H. Leonard, M. Gissler, J. Buxbaum, Kingsley Wong, D. Schendel, A. Kodesh, M. Breshnahan, S. Levine, E. Parner, S. N. Hansen, C. Hultman, A. Reichenberg, S. Sandin   +21 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The interplay of aging, genetics and environmental factors in the pathogenesis of Parkinson’s disease

Translational Neurodegeneration, 2019
Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies (LB).
S. Pang, P. Ho, Hui-Fang Liu, Chi-Ting Leung, Lingfei Li, E. Chang, D. Ramsden, S. Ho   +7 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Effects of di(2-ethylhexyl) phthalate on glucose homeostasis in rats due to impaired autophagy flux of islet β cells mediated by oxidative stress

环境与职业医学
BackgroundDi(2-ethylhexyl) phthalate (DEHP) is the most prevalent environmental endocrine disruptor among phthalate acid esters (PAEs) worldwide. Previous studies have indicated that exposure to DEHP may disrupt glucose metabolism.ObjectiveTo investigate
Hongyang ZHOU, Yuting HU, Xue CHEN, Yunqiang ZHOU, Liping LI, Ling LI, Herong LIU   +6 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Host and Environmental Factors Affecting the Intestinal Microbiota in Chickens

Frontiers in Microbiology, 2018
The initial development of intestinal microbiota in poultry plays an important role in production performance, overall health and resistance against microbial infections. Multiplexed sequencing of 16S ribosomal RNA gene amplicons is often used in studies,
J. G. Kers, J. G. Kers, F. Velkers, Egil A. J. Fischer, Gerben D. A. Hermes, J. Stegeman, H. Smidt   +6 more
semanticscholar   +1 more source