Results 141 to 150 of about 971,459 (303)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Fishing for Understanding: A Mixed Logit Model of Freshwater Angler Preferences [PDF]

Freshwater fisheries management requires knowledge of not only the resource but angler preferences and the extent to which preferences vary. This paper reports results from an internet-based stated preference survey of anglers in the North Canterbury ...
Beville, Stephen, Kerr, Geoffrey N.
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Responses of Macroinvertebrate Communities to Heterogeneity Among Typical Reaches in the Upper Yangtze River

Ecology and Evolution
Benthic macroinvertebrates are important indicators of river ecosystem health, and their spatial distribution is highly sensitive to environmental heterogeneity. In large mountainous rivers characterized by complex geomorphology and strong hydrodynamics,
Yang Wei, Wang Si‐Yuan, Zhang Xian‐Bing, Zhang Yang‐Chun, Chen Zi‐Wei, Yang Zhong‐Chao, Yang Sheng‐Fa, Chen Qi‐Liang, Xie Jia‐Hui, Tan Li‐Wei   +9 more
doaj   +1 more source

Economics of new technologies for sustainable agriculture [PDF]

Sustainable agriculture is prescribed as a policy approach that maximizes economic benefits while maintaining environmental quality. It is argued that this approach is human capital-intensive and encourages new scientific developments.
Khanna, Madhu, Lipper, Leslie, Zilberman, David   +2 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Physiological and Epigenetic Responses of the Long‐Spined Sea Urchin Diadema antillarum Across a Spatiotemporal Gradient

Ecology and Evolution
Following catastrophic population declines in the 1980s and 2022, the keystone herbivore Diadema antillarum has become a focal species for Caribbean‐wide restoration initiatives. In the present work, we combined an 11‐month field survey across four reefs
Ibis T. Lopez‐Jimenez, Alex E. Mercado‐Molina, Juliet M. Wong, Jose Eirin‐Lopez   +3 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Extremely Fine‐Scale Soil Heterogeneity in a Rare Serpentine Endemic Plant Shape Patterns of Genetic Diversity

Ecology and Evolution
Studies of population genetic structure are typically conducted at the scale of species distributions and encompass large distances and substantial environmental variation.
Joseph Braasch, Julia G. Harenčár, Sarah Swope   +2 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source