Results 71 to 80 of about 5,915,013 (307)

Spatial patterns of congruence or mismatch between taxonomic, functional, and phylogenetic diversity and endemism of perennial flora along the aridity gradient of Chile

Frontiers in Plant Science
IntroductionUnderstanding the relationships between taxonomic, functional, and phylogenetic diversity and endemism across environmental gradients is essential for elucidating the eco-evolutionary mechanisms that shape local plant communities.MethodsA ...
Paola Poch, Paola Poch, Elie Poulin, Elie Poulin, María Fernanda Pérez, Gioconda Peralta, Luis Felipe Hinojosa   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

CO2 Emissions and Economic Activity: heterogeneity across countries and non stationary series [PDF]

This paper explores the homogeneity of the functional form, the parameters, and the turning point, when appropriate, of the relationship between CO2 emissions and economic activity for 31 countries (28 OECD, Brazil, China, and India) during the period ...
Emilio Padilla, Matías Piaggio
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Community structure and biodiversity of benthic macroalgae in the Shengsi Archipelago of the East China Sea

Frontiers in Marine Science
IntroductionThis study focused on benthic macroalgal communities in the Shengsi Archipelago, East China Sea, a region jointly influenced by pronounced environmental heterogeneity driven by the interplay of the Yangtze River diluted water and the Taiwan ...
Lingling Wang, Wantao Xu, Qijun Luo, Haimin Chen   +3 more
doaj   +1 more source

Strategic interactions and heterogeneity in a overlapping generations model with negative environmental externalities [PDF]

We analyze an overlapping generations model where individuals’ welfare depends on the stock of a free access environmental good E and on the consumption C of a private good.
Antoci, Angelo, Sodini, Mauro, Naimzada, Ahmad   +2 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Variation in Soil Bacterial and Fungal Diversity, Community Composition, and Co-Occurrence Patterns Across Nearshore Islands in the Northern South China Sea

Microorganisms
Soil microbial biogeography on nearshore islands remains less well understood than that on remote archipelagos, particularly when bacterial and fungal diversity, community composition, and co-occurrence associations are evaluated together.
Jian Gong, Yechen Qiao, Rui Pan, Hu Du, Xionghui Liao, Wanxia Peng   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source