Results 101 to 110 of about 2,717,832 (296)

Human exposure risk of organic UV filters: A comprehensive analysis based on primary exposure pathways

open access: yesEcotoxicology and Environmental Safety
The exposure of organic UV filters has been increasingly confirmed to induce adverse effects on humans. However, the critical exposure pathway and the vulnerable population of organic UV filters are not clearly identified. This paper attempts to evaluate
Fan Yang   +7 more
doaj   +1 more source

Life cycle assessment of constructed wetland systems for wastewater treatment coupled with microbial fuel cells [PDF]

open access: yes, 2017
The aim of this study was to assess the environmental impact of microbial fuel cells (MFCs) implemented in constructed wetlands (CWs). To this aim a life cycle assessment (LCA) was carried out comparing three scenarios: 1) a conventional CW system ...
Corbella Vidal, Clara   +2 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Developing Tools for Health Impact Assessment in Environmental Impact Assessment in Thailand [PDF]

open access: yes, 2011
The purpose of this research was to develop tools applicable to the Health Impact Assessment (HIA) in Environmental Impact Assessment (EIA) in a Thai context. The relevant documents and articles were extensively reviewed, analyzed, and drafted. The first
Hengpraprom, Sarunya   +1 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

European Union environmental regulations and their potential impact on market access for Africa's exports [PDF]

open access: yes
international trade;impact assessment;European Union;Africa;access to markets;environmental protection;exports;international agreements;environmental ...
Mihyo, P.B.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Ozone Response to Aircraft Emissions: Sensitivity Studies with Two-dimensional Models [PDF]

open access: yes, 1992
Our first intercomparison/assessment of the effects of a proposed high-speed civil transport (HSCT) fleet on the stratosphere is presented. These model calculations should be considered more as sensitivity studies, primarily designed to serve the ...
Brasseur, G.   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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