Results 81 to 90 of about 15,665,920 (290)

Constructing Mammal Occurrence Status and Deep Learning Training Data from Camera Trap Surveys in Wind Farm [PDF]

Geo Data
In South Korea, there has been an increase in the development of onshore wind farms as part of national strategies to achieve carbon neutrality. However, concerns have been raised regarding the potential ecological impacts on terrestrial mammals posed by
Dong-Joo Kim, Do-Hun Lee, Nanghee Kim, Jun-Haeng Heo, Yong Sung Kwon   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Occurrence Status of Legally Protected Species in Environmental Impact Assessment Reports [PDF]

Geo Data
In environmental impact assessments, the presence or absence of legally protected species is one of the important considerations when evaluating site feasibility.
Joohyun Seo, Hae-Ran Kim, Minho Chang, Nanghee Kim, Jinjoo Na, HaEun Lee, Jaegyu Cha, Jungkwon Kim   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Temporal variation in discharge coefficients of non-point source pollution and its determinants in river-network areas in a plain

Guan'gai paishui xuebao
【Objective】 Discharge coefficient is a coefficient describing the discharge of non-point source pollution to water bodies. It is affected by many biotic and abiotic factors.
DUANMU Jiayao, CHEN Cheng, CHEN Xiaohua, SHEN Genxiang, ZHANG Min, GUO Chunxia, WANG Zhenqi, BAI Yujie, LING Zhixiong, CAO Guomin   +9 more
doaj   +1 more source

Pesticide exposures and chronic kidney disease of unknown etiology: an epidemiologic review

Environmental Health, 2017
The main causes of chronic kidney disease (CKD) globally are diabetes and hypertension but epidemics of chronic kidney disease of unknown etiology (CKDu) occur in Central America, Sri Lanka, India and beyond.
Mathieu Valcke, Marie-Eve Levasseur, Agnes Soares da Silva, Catharina Wesseling   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effects of inhalation of polyhexamethylene guanidine disinfectant aerosol on immune organs and immune cells in mice

环境与职业医学
BackgroundThe respiratory toxicity of inhaled polyhexamethylene guanidine (PHMG) has been extensively studied since the humidifier disinfectant incident. However, the impacts of inhalation of PHMG on the immune system are not comprehensively studied yet.
Zhengli YANG, Naimin SHAO, Yu DING, Jing XU, Junli LIU, Xi LIU, Kelei QIAN, Xinyu HONG   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Nationwide distribution of perfluoroalkyl ether carboxylic acids in Chinese diets: An emerging concern

Environment International
With the phase-out of perfluorooctanoic acid (PFOA) and its replacement by perfluoroalkyl ether carboxylic acids (PFECAs), there is a potential for increased exposure to various new PFECAs among the general population in China.
Fengfeng Dong, Haijun Zhang, Nan Sheng, Jianglin Hu, Jiayin Dai, Yitao Pan   +5 more
doaj   +1 more source