Results 41 to 50 of about 2,735,682 (296)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effects and mechanisms of pesticide carbendazim on osteogenic differentiation

open access: yes环境与职业医学
BackgroundCarbendazim (CBZ), a widely used benzimidazole fungicide, has raised increasing concerns regarding the health risks associated with its residues.
Liming XUE   +4 more
doaj   +1 more source

Sustainable economic growth within environmental limits. volume 1: guidance for the east midlands [PDF]

open access: yes, 2010
LUC and GHK have developed a tool for setting environmental limits that local communities and other stakeholders can use. The three-step approach is based on the participation of the local community and other interested stakeholders, such as statutory ...
GHK Consulting, Land Use Consultants
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Removal mechanism of decabromodiphenyl ether in soil by Cu/Fe nanoparticles

open access: yesHygiene and Environmental Health Advances
Decabromodiphenyl ether (BDE-209), a widely used and environmentally significant legacy brominated flame retardant, is frequently found in farmland soil near electronic waste disposal sites and manufacturing facilities.
Siyuan Ling, Ying Han, Shuangqing Hu
doaj   +1 more source

Valuing Biodiversity in Life Cycle Impact Assessment [PDF]

open access: yes, 2019
Erratum published on 13 March 2020, see Sustainability 2020, 12(6), 2270. https://doi.org/10.3390/su11205628In this article, the authors propose an impact assessment method for life cycle assessment (LCA) that adheres to established LCA principles for ...
Bischoff, Mascha   +5 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs). [PDF]

open access: yes, 2017
The potential environmental impact of nanomaterials is a critical concern and the ability to assess these potential impacts is top priority for the progress of sustainable nanotechnology.
Bilal, Muhammad   +3 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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