Results 81 to 90 of about 2,717,832 (296)

Corporate environmental assessment by a bank lender : a social constructionist perspective [PDF]

open access: yes, 2001
Over the last decade evidence has emerged which suggests that lenders are considering environmental impact of corporate borrowers as part of their lending decisions. Environmental consideration by lenders may considerably influence the level of financial
Coulson, A.B.   +1 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Chemical carcinogenicity of neodymium nitrate in AML12 hepatocytes: Dose-response metabolomics and sensitive biomarker identification

open access: yesEcotoxicology and Environmental Safety
This study aims to investigate the chemical carcinogenic toxicity of neodymium nitrate (Nd(NO3)3) in mouse hepatocytes AML12 using dose-response metabolomics. Specifically, our objectives are to: Identify key metabolites that respond to Nd(NO3)3 exposure.
Ning Wang   +10 more
doaj   +1 more source

Environmental impact assessment of dietary scenarios: a comparison of methodological aspects [PDF]

open access: yes, 2018
Background Dietary patterns have manifold impacts on the environment. • However, studies that assess dietary patterns operate with varying methodological approaches and underlying assumptions, which evoke different, and occasionally even contradicting,
de Boer, Imke J.M.   +4 more
core  

Comparing the environmental impacts of meatless and meat-containing meals in the United States [PDF]

open access: yes, 2019
This study compares the environmental impacts of meatless and meat-containing meals in the United States according to consumption data in order to identify commercial opportunities to lower environmental impacts of meals.
Del Duce, Andrea   +5 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

VDAC1 Intervention Alleviates Bisphenol AF-Induced Succinate Metabolism Dysregulation and Inflammatory Responses

open access: yesPharmaceuticals
Background/Objectives: Bisphenol AF (BPAF) is a prevalent environmental contaminant with demonstrated metabolic and immunological toxicity. This study aimed to investigate whether VDAC1 (Voltage-Dependent Anion Channel 1) mediates BPAF-induced succinate ...
Xinyu Hong   +7 more
doaj   +1 more source

A Transnational Perspective on Extending NEPA: The Convention on Environmental Impact on Assessment in a Transboundary Context [PDF]

open access: yes, 1995
Introduction In recent years, the potential adverse impacts of transboundary pollution have received heightened attention both domestically and abroad.
Battle, Laura Carlan
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

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