Results 81 to 90 of about 2,466,142 (323)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The complete mitochondrial genome of Exopalaemon annandalei

open access: yesMitochondrial DNA. Part B. Resources, 2018
In this study, the complete mitochondrial genome (mitogenome) of Exopalaemon annandalei was amplified and analyzed. The mitogenome is 15,718 bp in length, encoding 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and a control region (CR ...
YiMing Yuan   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Distribution of trace and toxic element monitoring in soil samples from the lesser Himalayan region of India, pollution indices and source identification

open access: yesDiscover Environment
Monitoring toxic and trace elements in soil is vital for environmental protection, agricultural productivity, and regulatory compliance, yet tailored methodologies for comprehensive soil analysis are limited, particularly in ecologically sensitive ...
Mahesh Tiwari   +5 more
doaj   +1 more source

High-Resolution Mapping and Biomass Estimation of Suaeda salsa in Coastal Wetlands Using UAV Visible-Light Imagery and Hue Angle Inversion

open access: yesApplied Sciences
Unmanned Aerial Vehicles (UAVs) have become powerful tools for high-resolution, quantitative remote sensing in ecological and environmental studies. In this study, we present a novel approach to accurately mapping and estimating the biomass of Suaeda ...
Lin Wang   +6 more
doaj   +1 more source

The complete mitochondrial genome of Helice Sheni and its phylogenetic implication

open access: yesMitochondrial DNA. Part B. Resources, 2018
In this study, the complete mitochondrial genome (mitogenome) of Helice sheni was amplified and analyzed. The mitogenome is 16,062 bp in length, encoding the standard set of 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and one control region ...
YiMing Yuan   +5 more
doaj   +1 more source

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