Results 51 to 60 of about 1,616,058 (308)

Model for Malicious Node Recognition Based on Environmental Parameter Optimization and Time Reputation Sequence

Xibei Gongye Daxue Xuebao, 2020
Wireless sensor network (WSN) works in a complex environment. To interdict the malicious nodes which attacks the safety of network, such as interrupt attacks and selective forwarding attacks, based on TS-BRS reputation model, a model for malicious node ...

doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Parameter Sensitivity Analysis for Computationally Intensive Spatially Distributed Dynamical Environmental Systems Models

Journal of Advances in Modeling Earth Systems, 2019
Dynamical environmental systems models are highly parameterized, having large numbers of parameters whose values are uncertain. For spatially distributed continental‐scale applications, such models must be run for very large numbers of grid locations. To
Xueli Huo, Hoshin Gupta, Guo‐Yue Niu, Wei Gong, Qingyun Duan   +4 more
doaj   +1 more source

A novel method to jointly estimate transmission rate and decay rate parameters in environmental transmission models

Epidemics, 2023
In environmental transmission, pathogens transfer from one individual to another via the environment. It is a common transmission mechanism in a wide range of host-pathogen systems.
You Chang, Mart C.M. de Jong
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genetic and environmental dispersion parameter estimation by test interval method in dairy sheep

Acta Agriculturae Slovenica, 2011
Genetic and environmental parameters for 38 983 test-day records of daily milk yield (DMY), fat (FC) and protein (PC) content, collected between 1994 and 2002, were estimated on 3,068 dairy ewes of the three Slovenian breeds.
Andreja KOMPREJ, Dragomir KOMPAN, Milena KOVAČ   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Probabilistic analysis of empirical berm recession formulas considering environmental parameter dependence

Applied Ocean Research
Berm recession is a critical factor in the design and reliability assessment of rubble-mound berm breakwaters. However, the variability among empirical formulas introduces significant uncertainty in predicting structural performance.
Ali Jamali Rovesht, Mehdi Shafieefar, Hassan Akbari, Pouya Zarbipour   +3 more
doaj   +1 more source

Reduced density matrix hybrid approach: Application to electronic energy transfer

, 2011
Electronic energy transfer in the condensed phase, such as that occurring in photosynthetic complexes, frequently occurs in regimes where the energy scales of the system and environment are similar.
Breuer H.-P., David R. Reichman, Thomas E. Markland, Timothy C. Berkelbach   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source