Results 71 to 80 of about 1,616,058 (308)

On the Interplay between Entropy and Robustness of Gene Regulatory Networks

Entropy, 2010
The interplay between entropy and robustness of gene network is a core mechanism of systems biology. The entropy is a measure of randomness or disorder of a physical system due to random parameter fluctuation and environmental noises in gene regulatory ...
Bor-Sen Chen, Cheng-Wei Li
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Preliminary design study of a regenerative life support system information management and display system [PDF]

The instrumentation requirements for a regenerative life support systems were studied to provide the earliest possible indication of a malfunction that will permit degradation of the environment.
Parker, C. D., Tommerdahl, J. B.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

An improved optimization technique for estimation of solar photovoltaic parameters [PDF]

, 2017
The nonlinear current vs voltage (I-V) characteristics of solar PV make its modelling difficult. Optimization techniques are the best tool for identifying the parameters of nonlinear models.
Alam, Askarzadeh, Askarzadeh, Babu, Barth, Barukcic, Bayraktar, Bayraktar, Bhandari, C. Rani, Chan, Chatterjee, Chen, Derick, Dkhichi, Easwarakhanthan, El-Naggar, Farivar, Ishaque, Ishaque, Ismail, K. Busawon, M. Derick, M. Rajesh, M.E. Farrag, Ma, Ma, Oliva, Rajasekar, Rajesekar, Ram, Rezaee Jordehi, Wolf, Xiaoping, Y. Wang, Yuan   +35 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Did NEPA Drown New Orleans? The Levees, the Blame Game, and the Hazards of Hindsight [PDF]

, 2006
This Article highlights the. hazards of hindsight analysis of the causes of catastrophic events, focusing on theories of why the New Orleans levees failed during Hurricane Katrina in 2005 and particularly on the theory that the levee failures were ...
Kysar, Douglas A., McGarity, Thomas O.
core   +4 more sources

The role of environmental parameter (degree day) of snowmelt runoff simulation

Soil & Environment, 2011
The upper Indus basin comprises the high mountains covered with snow and glaciers. So the major portion of flowfrom Indus basin is due to snow and glacier melt runoff. The terrain is difficult to measure the hydrological andhydraulics data.
Ghulam Nabi*, Muhammad Latif, Habib-ur-Rehman and Aftab Hussain Azhar
doaj  

Surrogate chromatographic models and the solvation parameter model

Journal of Chromatography Open
Many partition processes of interest have been characterised using Abraham's solvation parameter model. However, to estimate physicochemical, environmental, or biophysical properties of compounds requires reliable solute descriptors.
Sanka N. Atapattu, Colin F. Poole
doaj   +1 more source