Results 91 to 100 of about 13,359,027 (313)

Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review

International Journal of Environmental Research and Public Health, 2019
Environmental factors are recognized as risk factors of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout or medical radiation, and to some organic and inorganic chemical toxicants represent a worldwide public health ...
M. Fiore, G. Oliveri Conti, R. Caltabiano, A. Buffone, P. Zuccarello, L. Cormaci, M. Cannizzaro, M. Ferrante   +7 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Water Quality Criteria of Dieldrin for the Protection of Aquatic Organisms and Wildlife Using a Tissue Residue Approach

Toxics
Dieldrin is legacy organochlorine insecticide, which was listed in the Stockholm Convention because of its persistence, bioaccumulation and toxicity. However, it is still present in the environment and in organisms two decades after its ban.
Li Xie, Xuemei Li, Liangwen Bao, Yuexin Zhang, Hailei Su, Xuesong Liu, Fanfan Wang, Yuan Wei, Ningning Ji, Min Zhou   +9 more
doaj   +1 more source

Environmental Risk Factors for Congenital Heart Disease.

Cold Spring Harbor Perspectives in Biology, 2019
Congenital heart disease (CHD) has many forms and a wide range of causes. Clinically, it is important to understand the causes. This allows estimation of recurrence rate, guides treatment options, and may also be used to formulate public health advice to
J. Kalisch-Smith, N. Ved, D. Sparrow
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Environmental Risk Factors Associated with Child Stunting: A Systematic Review of the Literature

Annals of Global Health, 2018
Background: Stunting, a form of malnutrition characterized by impaired linear growth in the first two years of life, affects one quarter of children globally.
D. Vilcins, P. Sly, P. Jagals
semanticscholar   +1 more source

Risk Evaluation of Environmental Carcinogens

Journal of Occupational Health, 1996
Risk Evaluation of Environmental Car cinogens: Shigeaki Sato. Department of Hygiene, Kobe University School of Medicine—Quantitative risk evaluation of environmental carcinogens is required not only for their regulation but also for primary cancer prevention.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review

International Journal of Environmental Research and Public Health, 2018
Different elements of the environment have been posited to influence type 2 diabetes mellitus (T2DM). This systematic review summarizes evidence on the environmental determinants of T2DM identified in four databases.
Tashi Dendup, Xiaoqi Feng, Stephanie Clingan, T. Astell‐Burt   +3 more
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source