Results 81 to 90 of about 1,490,052 (312)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comment on "Rachel Oliver's article on religion and environment"

, 2008
I enjoyed reading Rachel Oliver's article on religion and environment. These differences (both between and within religions) in how people see the relation between mankind, nature and God are quite interesting ...
Environmental risk management, Wardekker, J.A., Dep Scheikunde   +2 more
core  

Exploring the quality of evidence for complex and contested policy decisions

, 2008
Policy decisions on complex environmental risks often involve contested science. Typically there are no 'facts' that entail a unique correct policy. The evidence that is embodied in scientific policy advice requires quality assessment.
Environmental risk management, van der Sluijs, J.P., Petersen, A.C., Risbey, J.S., Dep Scheikunde, Ravetz, J., Janssen, P.H.M.   +6 more
core   +1 more source

Environmental Planning for Disaster Risk Reduction at Kaduna International Airport, Kaduna Nigeria

, 2020
The compatibility of an airport with its environs can be achieved by proper environmental control and planning of the airport, control of pollution-generating sources, and land use planning of the area surrounding the airport are paramount if disasters ...
Hussaini, Abdullahi
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Sleep disruption with aging in senescence-accelerated mice-prone 8 (SAMP8) mice and analysis of factors associated with age-related sleep fragmentation using RNA sequencing of the hypothalamus

Neurobiology of Sleep and Circadian Rhythms
Aging is a risk factor for various disorders, and age-dependent changes in sleep parameters are involved in the pathogenesis of many diseases. Senescence-accelerated mice-prone 8 (SAMP8) have a short lifespan and show a disrupted circadian rhythm ...
Kazuyuki Okamura, Rie Yanagisawa, Miyuki Sato, Takehiro Suzuki, Nobuyoshi Nakajima, Tin-Tin Win-shwe, Eiko Koike   +6 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Characteristics of PM10 Chemical Source Profiles for Geological Dust from the South-West Region of China

Atmosphere, 2016
Ninety-six particulate matter (PM10) chemical source profiles for geological sources in typical cities of southwest China were acquired from Source Profile Shared Service in China. Twenty-six elements (Na, Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu,
Yayong Liu, Wenjie Zhang, Zhipeng Bai, Wen Yang, Xueyan Zhao, Bin Han, Xinhua Wang   +6 more
doaj   +1 more source

Home Environmental Health Risks

OJIN: The Online Journal of Issues in Nursing, 2007
Home environmental health risks and the pollution of indoor residential air are becoming increasingly recognized as sources of injury and exacerbation of illness, particularly in vulnerable populations such as pregnant women, infants, children, the elderly, and those living with a chronic medical condition or disability.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source