Results 61 to 70 of about 1,490,052 (312)

Environmental risk and bank lending

, 2023
Belief in the effects of climate change remains stubbornly regionally specific. This column discusses how banks assess environmental risks in syndicated loan markets in the US.
Ongena, Steven; https://orcid.org/, Erten, Irem   +1 more
core  

Environmental risk and meningitis epidemics in Africa. [PDF]

, 2003
Epidemics of meningococcal meningitis occur in areas with particular environmental characteristics. We present evidence that the relationship between the environment and the location of these epidemics is quantifiable and propose a model based on ...
Stephen J. Connor, Anna M. Molesworth, Molesworth, Anna M., Connor, Stephen J, Connor, Stephen J., Thomson, Madeleine C., Cuevas, Luis E, Morse, Andrew P., Molesworth, Anna M, Andrew P. Morse, Luis E. Cuevas, Thomson, Madeleine C, Morse, Andrew P, Madeleine C. Thomson, Cuevas, Luis   +14 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Codon usage bias is presumably affected by tRNA selection effects in Actinidia polyploidization events

BMC Genomics
Background Polyploidization is one of the main mechanisms in speciation, yet its effects on the frequency and distribution of synonymous codons remain unclear, which may lead to distinct patterns of codon usage bias (CUB) in polyploid species.
Yi Zhou, Zhilu Sheng, Dongbin Li, Wencui Li, Yujia Peng, Zhaopeng Song, Zhanjun Quan, Yongbo Liu   +7 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

What Do We Know About Breast Cancer Risk Tip Sheet

, 2001
Tip Sheet on known and possible breast cancer risk factorsBreast cancer risk factors are like pieces of a puzzle. This Tip Sheet provides basic information in a brochure format on the known and possible risk factors for breast cancer.
Program on Breast Cancer and Environmental Risk Factors
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Environmental Health Risk [PDF]

, 2016
This book, Environmental Health Risk - Hazardous Factors to Living Species, is intended to provide a set of practical discussions and relevant tools for making risky decisions that require actions to reduce environmental health risk against environmental

core   +2 more sources

A novel-approach for identifying sources of fluvial DOM using fluorescence spectroscopy and machine learning model

npj Clean Water
Rivers are well known as one of the most threatened aquatic environments, whose structure and water quality can be deeply impacted by intensive anthropogenic activities.
Dongping Liu, Lei Nie, Beidou Xi, Hongjie Gao, Fang Yang, Huibin Yu   +5 more
doaj   +1 more source