Results 21 to 30 of about 502,413 (242)

Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

open access: yesBMC Medical Genomics, 2020
Background Circular RNAs are non-coding RNA molecules with gene regulatory potential that have been associated with several human diseases. They are stable and present in the circulation, making them excellent candidates for biomarkers of disease ...
Shahnaz Haque   +5 more
doaj   +1 more source

The economical lifestyle of CPR bacteria in groundwater allows little preference for environmental drivers

open access: yesEnvironmental Microbiome, 2021
Background The highly diverse Cand. Patescibacteria are predicted to have minimal biosynthetic and metabolic pathways, which hinders understanding of how their populations differentiate in response to environmental drivers or host organisms.
Narendrakumar M. Chaudhari   +8 more
doaj   +1 more source

Highly Conserved RNA Sequences That Are Sensors of Environmental Stress [PDF]

open access: yesMolecular and Cellular Biology, 1998
The putative function of highly conserved regions (HCRs) within 3' untranslated regions (3'UTRs) as regulatory RNA sequences was efficiently and quantitatively assessed by using modular retroviral vectors. This strategy led to the identification of HCRs that alter gene expression in response to oxidative or mitogenic stress. Databases were screened for
Spicher, A.   +7 more
openaire   +3 more sources

SARS-CoV-2 RNA detection on environmental surfaces in COVID-19 wards

open access: yesPLoS ONE, 2023
This study monitored the presence of SARS-Cov-2 RNA on environmental surfaces in hospital wards housing patients with mild, severe, and convalescent Coronavirus Disease 2019 (COVID-19), respectively.
Xuan Zhou   +5 more
doaj   +2 more sources

Potential Role of Domains Rearranged Methyltransferase7 in Starch and Chlorophyll Metabolism to Regulate Leaf Senescence in Tomato

open access: yesFrontiers in Plant Science, 2022
Deoxyribonucleic acid (DNA) methylation is an important epigenetic mark involved in diverse biological processes. Here, we report the critical function of tomato (Solanum lycopersicum) Domains Rearranged Methyltransferase7 (SlDRM7) in plant growth and ...
Yu Xin Wen   +9 more
doaj   +1 more source

Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles

open access: yesMolecular Therapy: Nucleic Acids, 2017
RNA molecules have emerged as promising therapeutics. Like all other drugs, the safety profile and immune response are important criteria for drug evaluation. However, the literature on RNA immunogenicity has been controversial.
Sijin Guo   +5 more
doaj   +1 more source

Evaluation of Sequencing Library Preparation Protocols for Viral Metagenomic Analysis from Pristine Aquifer Groundwaters

open access: yesViruses, 2019
Viral ecology of terrestrial habitats is yet-to be extensively explored, in particular the terrestrial subsurface. One problem in obtaining viral sequences from groundwater aquifer samples is the relatively low amount of virus particles. As a result, the
René Kallies   +6 more
doaj   +1 more source

Identification of differentially expressed genes involved in spore germination of Penicillium expansum by comparative transcriptome and proteome approaches

open access: yesMicrobiologyOpen, 2018
In this study, Penicillium expansum, a common destructive phytopathogen and patulin producer was isolated from naturally infected apple fruits and identified by morphological observation and rDNA‐internal transcribed spacer analysis.
Ting Zhou   +6 more
doaj   +1 more source

Environmentally-Induced Transgenerational Epigenetic Inheritance: Implication of PIWI Interacting RNAs [PDF]

open access: yesCells, 2019
Environmentally-induced transgenerational epigenetic inheritance is an emerging field. The understanding of associated epigenetic mechanisms is currently in progress with open questions still remaining. In this review, we present an overview of the knowledge of environmentally-induced transgenerational inheritance and associated epigenetic mechanisms ...
Karine Casier   +3 more
openaire   +4 more sources

Environmental change exposes beneficial epistatic interactions in a catalytic RNA [PDF]

open access: yesProceedings of the Royal Society B: Biological Sciences, 2012
Natural selection drives populations of individuals towards local peaks in a fitness landscape. These peaks are created by the interactions between individual mutations. Fitness landscapes may change as an environment changes. In a previous contribution, we discovered a variant of the Azoarcus group I ribozyme that ...
Hayden Eric, Wagner Andreas
openaire   +3 more sources

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