Results 31 to 40 of about 525,778 (258)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Altered cofactor recruitment and nucleosome dynamics underlie bisphenol A’s impact on ERα-mediated transcriptional bursting

iScience
Summary: Transcription initiation at hormone-responsive gene promoters involves recruitment of numerous proteins that initiate stochastic events known as transcriptional bursts.
Christopher R. Day, Pelin Yaşar, Gloria Adedoyin, Brian D. Bennett, Carson C. Chow, Joseph Rodriguez   +5 more
doaj   +1 more source

Environmental RNA can distinguish life stages in amphibian populations

Molecular Ecology Resources, 2023
AbstractApplications of environmental DNA (eDNA) analysis methods for biomonitoring have grown exponentially over the last decade and provide a wealth of new information on the distribution of species. However, eDNA methods have limited application for estimating population‐level metrics. Environmental RNA (eRNA) has the potential to address ecological
Meghan B. Parsley, Caren S. Goldberg
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Poly(A) tail regulation in stem cells and early development

Cell Regeneration
Eukaryotic mRNAs are polyadenylated at their 3’-ends, and the poly(A) tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation.
Xiaosu Miao, Guang Hu
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Guanine quadruplexes mediate mitochondrial RNA polymerase pausing

BMC Biology
Background The information content within nucleic acids extends beyond the primary sequence to include secondary structures with functional roles in transcription regulation.
Ryan J. Snyder, Uma Shankar, Don Delker, Winny Soerianto, Joshua T. Burdick, Vivian G. Cheung, Jason A. Watts   +6 more
doaj   +1 more source

The Promise of Environmental RNA Research Beyond mRNA

Molecular Ecology
ABSTRACTEnvironmental RNA (eRNA) studies have primarily focused on species detection and community composition through metabarcoding or metatranscriptomics, and on gene expression through messenger RNA (mRNA) abundance analysis. While valuable, this focus overlooks the broader functional roles of other RNA types in cellular metabolism.
Ehsan Pashay Ahi, Tamara Schenekar
openaire   +2 more sources