Results 51 to 60 of about 1,462,954 (247)

Strategic intervention materials-based instruction on disaster literacy for technology students using the ADDIE model

open access: yesFrontiers in Education
Disaster literacy among technology students is crucial for effective disaster management, especially in the Philippines, a country prone to natural hazards.
Romel C. Mutya   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Where to restore: Connectivity forest for spatial prioritization in forest landscape restoration

open access: yesiScience
Summary: Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical.
Xiaoming Wang   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Disparities in ambient air pollution exposure among the U.S. population amid climate change

open access: yesiScience
Summary: Air pollution and climate change remain critical environmental challenges. Using integrated modeling (global change analysis model [GCAM] and TM5-FASST), we assess future U.S.
Fatemeh Ganji   +6 more
doaj   +1 more source

PanAfrican Journal of Governance and Development (Full Issue)

open access: yesPanAfrican Journal of Governance and Development, 2020
The PanAfrican Journal of Governance and Development (PJGD) is a peer-reviewed biannual, multi-, inter-, and trans-disciplinary journal that publishes editorials, articles, essays, book reviews, commentaries and notes on issues related to democracy, good
Center For PanAfrican Journal of Governance and Development
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Heterogeneous impacts of fear and policy on building energy use during COVID-19 in South Korea

open access: yesiScience
Summary: The COVID-19 pandemic created a unique natural experiment in energy consumption, fundamentally reshaping demand. We analyzed electricity use in over one million South Korean buildings across six functional categories (May 2020 to April 2022 ...
Jonghyun Yoo, Daewon Kim, Minjung Kim
doaj   +1 more source

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