Results 71 to 80 of about 11,919,473 (381)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Making climate reanalysis and CMIP6 data processing easy: two “point-and-click” cloud based user interfaces for environmental and ecological studies

Frontiers in Environmental Science
Climate reanalysis and climate projection datasets offer the potential for researchers, students and instructors to access physically informed, global scale, temporally and spatially continuous climate data from the latter half of the 20th century to ...
James M. Lea, Robert N. L. Fitt, Stephen Brough, Stephen Brough, Georgia Carr, Jonathan Dick, Natasha Jones, Richard J. Webster   +7 more
doaj   +1 more source

Suppression of Environmental Science

American Journal of Law & Medicine, 2004
There is a long history of attacks on scientists. During the Inquisition, the Roman Catholic Church charged Galileo with heresy and, after imprisonment and threats of torture, forced him to renounce his theory that the sun, not the earth, was the center of the universe.
openaire   +4 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

The Role of Digital Technologies in Responding to the Grand Challenges of the Natural Environment: The Windermere Accord

Patterns, 2021
Summary: Digital technology is having a major impact on many areas of society, and there is equal opportunity for impact on science. This is particularly true in the environmental sciences as we seek to understand the complexities of the natural ...
Gordon S. Blair, Richard Bassett, Lucy Bastin, Lindsay Beevers, Maribel Isabel Borrajo, Mike Brown, Sarah L. Dance, Ada Dionescu, Liz Edwards, Maria Angela Ferrario, Rob Fraser, Harriet Fraser, Simon Gardner, Peter Henrys, Tony Hey, Stuart Homann, Chantal Huijbers, James Hutchison, Phil Jonathan, Rob Lamb, Sophie Laurie, Amber Leeson, David Leslie, Malcolm McMillan, Vatsala Nundloll, Oluwole Oyebamiji, Jordan Phillipson, Vicky Pope, Rachel Prudden, Stefan Reis, Maria Salama, Faiza Samreen, Dino Sejdinovic, Will Simm, Roger Street, Lauren Thornton, Ross Towe, Joshua Vande Hey, Massimo Vieno, Joanne Waller, John Watkins   +40 more
doaj  

4-H boosts youth scientific literacy with ANR water education curriculum

California Agriculture, 2012
Scientific literacy among K-12 youth in the United States needs to be improved, and UC Agriculture and Natural Resources has identified this as a key area for research and extension.
Martin Smith, Katherine Heck, Steven Worker   +2 more
doaj   +1 more source

Assessment of the Perceptions of Pre-service Teachers towards Practical Work in the Context of Scientific-technological Literacy

HighTech and Innovation Journal, 2020
This research aims to analyse the perceptions of future preschool teachers towards the application of practical work. This study is part of a more comprehensive teaching innovation project which aims to contribute to the scientific and technological ...
Lourdes Aragón
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source