Results 101 to 110 of about 9,766,647 (363)

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Physics, Environment and Environmental Education; Perceptions from trainee Natural Science teachers [PDF]

Environmental Education (EE) is vital for shaping citizens who understand and value sustainability as an epistemological and practical alternative to mitigate current environmental issues. This research was prompted by the exploration of the relationship between EE and the physical sciences, connections that are often overlooked in curriculums and in ...
arxiv   +1 more source

Growing South Dakota (Winter 2019) [PDF]

, 2019
This is issue contains the South Dakota Agricultural Experiment Station 2018 Annual Report, and the SDSU Extension 2018 Annual Report. [Page] 2 Setting Into role as Dean [Page] 4 Raven Precision Ag Center Groundbreaking Ceremony [Page] 10 Collaborating ...
Environmental Sciences, College of Agriculture, Food and
core   +1 more source

Natural sciences and environmental issues: a contribution from the philosophy of environmental sciences

International Journal of Environment and Health, 2017
The environmental issue has been considered a 'starting point' for certain epistemological transformations that aim at rethinking the way of performing science and interpreting the nature-society relationship. In this paper, we will explore controversial disputes in the natural science field through the analysis of a particular case study: the socio ...
Klier, Gabriela Ruth, Busan, Tomás Emilio, Di Pasquo, Federico Martín, Blois, Paula, Francese, Christian Federico, Folguera, Guillermo   +5 more
openaire   +3 more sources

Methods of Dendrochronology - Applications in the Environmental Sciences

, 1991
Some Historical Background on Dendrochronology.- Primary Data.- Data Analysis.- Methods of Calibration, Verification, and Reconstruction.- Tree-Ring/Environment Interactions and Their Assessment.- Tree Rings in the Study of Future Change.
D. Yamaguchi, E. Cook, L. Kairiûkštis
semanticscholar   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Pez: Phylogenetics for the Environmental Sciences

Bioinform., 2015
UNLABELLED pez is an R package that permits measurement, modelling and simulation of phylogenetic structure in ecological data. pez contains the first implementation of many methods in R, and aggregates existing data structures and methods into a single,
W. Pearse, M. Cadotte, J. Cavender-Bares, A. Ives, C. Tucker, S. Walker, Matthew R. Helmus   +6 more
semanticscholar   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Co-Constructing “Third Spaces” for Engagement with and for Minoritized Community Groups and Environmental Scientists

Earth Science, Systems and Society
The demographics of environmental and Earth scientists are not representative of the UK’s multicultural society. We sought to widen diversity and engage equitably through two related engaged research projects, “Walking the Walk” and “Landscape Stories ...
Richard Holliman, Geeta Ludhra, Clare Janet Warren, Anjana Khatwa, Yoseph Araya, Kelly Smith, Janice Ansine, Marcus Peter Sebastian Badger   +7 more
doaj   +1 more source