Results 61 to 70 of about 14,196,521 (400)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Geospatial Technology In Environmental Impact Assessments – Retrospective.

Present Environment and Sustainable Development, 2015
Environmental Impact Assessments are studies conducted to give us an insight into the various impacts caused by an upcoming industry or any developmental activity. It should address various social, economic and environmental issues ensuring that negative
Goparaju Laxmi
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Modeling the Growth Dynamics of Logistics Performance: Industrialization, Environmental Technology, and Economic Transformation in Manufacturing Economies

Systems
Global manufacturing economies have faced logistics performance challenges in recent decades. This study investigates the influence of industrialization, environmental technology, trade openness, foreign direct investment, and economic growth on the ...
Umar Hayyat, Li Qian, Maleeha Saeed, Wajid Nawaz   +3 more
doaj   +1 more source

Teachers’ Sensitivity towards Technology and Environmental Ethics

Education Sciences, 2018
The purpose of the current study was to determine the science and classroom teachers’ ethical sensitivities towards the issues of technology and the environment. Thus, the current study was conducted on 239 science and classroom teachers.
Busra Ceyhan, Nurettin Sahin
doaj   +1 more source

Application Research of Information Technology in Environmental Protection [PDF]

E3S Web of Conferences, 2019
With the rapid development of information technology, the application of information technology in the field of environmental protection tends to be frequent, which is of great significance to environmental protection. This paper analyzes the application
Yang Xianli, Ren Lili, Li Ning
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Bifurcation of environmental safety: Science and technology [PDF]

E3S Web of Conferences
The paper analyzes the provisions of the domestic legislative base and legal doctrine on the discussion issues of substantive and essential parameters of the category of environmental safety of the state.
Lang Petr
doaj   +1 more source