Results 201 to 210 of about 1,215,941 (358)

Ice-binding protein's dual roles for prolonging the enzymatic activity of alcohol dehydrogenase against freezing. [PDF]

Int J Biol Macromol
Aguirre D, Nieblas I, Gonzalez A, Zempel EL, Rounds BA, Wang TY, Chou TF, Cheng A, Asamoah J, Liu K, Reyes A, Scott CE, Wen X.   +12 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Variations of digestive enzymatic activity of the longarm river prawn, Macrobrachium tenellum (Smith 1871) adapted from the wild to culture with prepared meals

, 2021
Rodolfo De los Santos Romero, Carlos Alfonso Álvarez‐González, Emyr Saúl Peña‐Marín, Edilmar Cortés‐Jacinto, Luis Héctor Hernández Hernández, Marcelo Garcı́a-Guerrero   +5 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Methods for Assessing MAGL Enzymatic Activity: An Extensive Review of Past and Emerging Approaches. [PDF]

Int J Mol Sci
Bononi G, Landucci E, Di Stefano M, Piazza L, Bertini S, Macchia M, Granchi C.   +6 more
europepmc   +1 more source

Changes in enzymatic activity of the arable soil layer under different systems of primary tillage and fertilization of typical chernozem in the short crop rotation of the right-bank forest-steppe zone of Ukraine

, 2019
І. Prymak, O. Panchenko, Mykhailo Fedorchuk, Oksana Yeremenko, І. А. Panchenko   +4 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effect of Water Restriction and Rehydration on Haemato-Biochemical, Enzymatic and Hormonal Activity of Hoggets during Summer Season

, 2007
Nitin R. Patel, Rakesh J. Modi, Manzarul . Islam, Kishan N. Wadhwani   +3 more
openalex   +1 more source