Results 41 to 50 of about 1,215,941 (358)

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Early prediction of phenotypic severity in Citrullinemia Type 1

Annals of Clinical and Translational Neurology, 2019
Objective Citrullinemia type 1 (CTLN1) is an inherited metabolic disease affecting the brain which is detectable by newborn screening. The clinical spectrum is highly variable including individuals with lethal hyperammonemic encephalopathy in the newborn
Matthias Zielonka, Stefan Kölker, Florian Gleich, Nicolas Stützenberger, Sandesh C. S. Nagamani, Andrea L. Gropman, Georg F. Hoffmann, Sven F. Garbade, Roland Posset, the Urea Cycle Disorders Consortium (UCDC) and the European Registry and Network for Intoxication type Metabolic Diseases (E‐IMD) Consortia Study Group   +9 more
doaj   +1 more source

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds [PDF]

, 2010
RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African ...
Alibu, Vincent P., Barrett, Michael P., Gilbert, Ian H., Norval, Suzanne, Read, Kevin D., Ruda, Gian Filippo, Wong, Pui Ee   +6 more
core   +4 more sources

Antioxidant profiling in bael (Aegle marmelos Correa.) genotypes

Journal of Horticultural Sciences
The present investigation was undertaken to characterize the non-enzymatic and enzymatic antioxidant activities among 18 bael genotypes. Amongst the bael genotypes, highest marmelosin was observed in ‘Pant Bael-1’, at par with ‘Pant Bael-15’ and ‘Pant ...
A Kholia, K K Misra, R Rai, N Singh
doaj   +1 more source

Influence of season, environment and feeding habits on the enzymatic activity of peptidase and β-glucosidase in the gastrointestinal tract of two Siluriformes fishes (Teleostei)

Zoologia (Curitiba), 2013
The enzymatic activities involved in the digestion of proteins and carbohydrates were compared among three organs of the digestive track of two Siluriformes fish species, and between two areas: a reservoir, and an area downriver of it.
Silvana Duarte, Marco A. R. Paiva, Camila C. Lara, Marcelo P. Bemquerer, Francisco Gerson Araújo   +4 more
doaj   +1 more source

A closer look at ARSA activity in a patient with metachromatic leukodystrophy. [PDF]

, 2019
Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease mainly caused by a deficiency of arylsulfatase A activity. The typical clinical course of patients with the late infantile form includes a regression in motor skills ...
Childers, Anna, Clark, Matthew, Doherty, Kathleen, Duis, Jessica, Frazier, S. Barron, Pruthi, Sumit, Wenger, David A.   +6 more
core   +2 more sources

Air-drying pretreatment effect on soil enzymatic activity

Plant, Soil and Environment, 2017
Air-drying of soil samples is a common practice for all-purpose soil testing. However, it may cause the cessation of microbial activity changing the biochemical attributes.
Rodrigo Santos MOREIRA, Marcio Koiti CHIBA, Stefany Batista NUNES, Isabella Clerici de MARIA   +3 more
doaj   +1 more source

NMR studies of membrane structure and dynamics [PDF]

, 1978
Over the past decade, there has been considerable interest in the motional state of the phospholipid bilayer membrane. The motivation underlying these efforts has been the contention that the phospholipid bilayer is the basic matrix in which membrane ...
Bocian, David F., Chan, Sunney I.
core   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source