Results 91 to 100 of about 4,916 (237)

Do We Really Know How to Manage Anticoagulated Patients for Periodontal Nonsurgical Therapy? An Observational Cohort Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objectives The aim of this work is to assess and compare the impact of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKA) during and immediately after periodontal nonsurgical therapy. Materials and Methods A prospective observational cohort study was conducted with patients who presented a history of cardiovascular disease ...
F. Berton, A. Rapani, F. Costantinides, V. Nicolin, D. Cuhureanu, R. Di Lenarda   +5 more
wiley   +1 more source

Distinct Microbiota and Functional Pathway Profiles Define Success and Failure in Regenerative Endodontic Treatment

International Endodontic Journal, EarlyView.
ABSTRACT Aim To characterize the intracanal microbiota and identify key microbial taxa and functional pathways associated with regenerative endodontic treatment (RET) outcomes. Methodology In this observational cohort study, 196 samples were collected at five time points from external tooth surfaces (T1, T4) and root canals (T2, T3, T5).
Leimarembi Devi Naorem, Alina Wikström, Peter Quach, Lokeshwaran Manoharan, Ronald Ordinola‐Zapata, Olena Rakhimova, Malin Brundin, Nelly Romani Vestman   +7 more
wiley   +1 more source

The interdisciplinary management of Severe burns in pregnancy

Burns Open, 2017
Background: Severe burns in pregnant women present an exceedingly challenging situation due to the limitation in therapeutic options including pain management and operative care.Case: We present a 30 years old patient, 38th week of pregnancy, who ...
Christoph Wallner, Peter Kern, Norbert Teig, Marcus Lehnhardt, Björn Behr   +4 more
doaj   +1 more source

A retrospective review of an off-label bromelain-based selective enzymatic debridement (Nexobrid®) in the treatment of deep, partial, and full thickness burns and hard to heal wounds

, 2020
Background: Rapid and selective bromelain-based enzymatic debridement provides a non-surgical alternative for the eschar removal in deep burns, which allows for early debridement of large surface areas, accurate evaluation of burn and wound depth, and ...
Moti Harats (11356767), Josef Haik (11356755), Ilan Vashurin (11369121), Michelle L Cleary (11353185), Rachel Komhaber (11369124), Uri Aviv (11356752)   +5 more
core   +2 more sources

Evidence-Based Management of Burns: A Narrative Review of Evolving Practices

European Burn Journal
Background: The last decade has seen transformative changes in burn care, driven by advances in pharmacology, regenerative medicine, surgical techniques, and digital technologies.
Anna Jolly Neriamparambil, Raja Sawhney, Wei Lun Wong   +2 more
doaj   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Japanese Consensus Document on NexoBrid^®, a Burn Eschar Removal Agent

European Burn Journal
Background: NexoBrid® (NXB), an enzymatic debridement agent approved in Japan in 2022, provides a less invasive alternative to surgical excision for burn treatment.
Hajime Matsumura, Takahiro Ueda, Rei Ogawa, Yasuhiko Kaita, Hiroyuki Sakurai, Kazutaka Soejima, Junichi Sasaki   +6 more
doaj   +1 more source

Enzymatic debridement after mobile phone explosion: A case report [Détersion enzymatique après explosion de téléphone mobile: À propos d’un cas] [PDF]

, 2016
It is estimated that over 90% of people own a mobile phone. Although rare, lithium-ion battery explosions can cause varying degrees of thermal burn injury. Recently, selective enzymatic debridement has gained importance in the management of burn patients,
CHERUBINO, MARIO, Sallam, D., VALDATTA, LUIGI, Pulerà, E., PELLEGATTA, IGOR   +4 more
core  

Enzymatic debridement as a non-traumatic alternative for safe early escharectomy

, 2016
Early escharectomy stands as a cornerstone in the treatment of deep burns. While effective, the procedure is demanding in terms of personnel, and traumatic: blood losses can easily reach 100 ml per % TBSA excised with profound effects on the patient ...
Tocco-Tussardi I, Presman B, Heedman R, Huss Fredrik   +3 more
core   +1 more source

Hypoxia‐preconditioned adipose‐derived mesenchymal stem cells‐derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5‐mediated inactivation of TLR4/NF‐κB/NLRP3 inflammatory signaling

Journal of Diabetes Investigation, EarlyView.
In this study, we uncovered that Hypo‐Exo transferring H19 promoted diabetic wound healing by repressing NETs formation via the miR‐130a/b‐3p/HOXA5 pathway to inactivate the TLR4/NF‐κB/NLRP3 inflammatory signaling. ABSTRACT Background Hypoxia‐stimulated adipose‐derived mesenchymal stem cells (ADSCs)‐derived exosomes (Hypo‐Exo) have a positive impact on
Li Qian, Xianxi Meng, Bairong Fang, Li Pi   +3 more
wiley   +1 more source