The accuracy of burn depth diagnosis: Clinical assessment before and after enzymatic debridement
Burns Open, 2021 Introduction: The most common technique used to determine burn depth is clinical assessment by experienced burn surgeons, although this has been shown to be reliable in only 60–75% of the cases. Overestimation of burn depth may result in needles surgery,
Ilaria Mataro +8 more
doaj +1 more source
Delayed enzymatic debridement in severe burns: Proof of concept
Burns Open, 2021 Introduction: Enzymatic debridement (ED) is a novel powerful therapy for debridement of severe burns. Standard ED is usually performed within 72 h after injury following a presoaking phase.
M. Waldner +8 more
doaj +1 more source
Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]
, 2020 Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B. +12 more
core +1 more source
Pyoderma Gangrenosum After Enzymatic Debridement [PDF]
Journal of General Internal Medicine, 2015 A n 80-year-old man with a history of IgA monoclonal gammopathy presented with a painful ulcerative lesion on his right knee (Fig. 1) that had developed in response to a lanced pustule. Failure of empiric antibiotics led to a punch biopsy, which showed nonspecific acute and chronic inflammation.
Mark, Duncan, Scott, Worswick
openaire +2 more sources
Identification and Characterization of Novel Matrix-Derived Bioactive Peptides: A Role for Collagenase from Santyl® Ointment in Post-Debridement Wound Healing? [PDF]
PLoS ONE, 2016 Debridement, the removal of diseased, nonviable tissue, is critical for clinicians to readily assess wound status and prepare the wound bed for advanced therapeutics or downstream active healing.
Anthony R Sheets +5 more
doaj +1 more source
Autolysis: mechanisms of action in the removal of devitalised tissue [PDF]
, 2016 Chronic wounds affect millions of people worldwide. In the UK alone, the cost of their treatment is estimated to be between £4.5bn and £5.1bn. The implementation of wound-bed preparation strategies remove the barriers to healing and wound debridement is ...
Albaugh K +9 more
core +1 more source
Enzymatic Debridement in Necrotizing Pancreatitis [PDF]
International Surgery, 2015 Multiple organ failure and pancreatic necrosis are the factors that determine prognosis in acute pancreatitis attacks. We investigated the effects of collagenase on the debridement of experimental pancreatic necrosis. The study covered 4 groups; each group had 10 rats. Group I was the necrotizing pancreatitis group.
Cakir, Murat +4 more
openaire +2 more sources
The Debrisoft ® monofilament debridement pad for use in acute or chronic wounds: A NICE medical technology guidance [PDF]
, 2015 As part of its Medical Technology Evaluation Programme, the National Institute for Health and Care Excellence (NICE) invited a manufacturer to provide clinical and economic evidence for the evaluation of the Debrisoft ® monofilament debridement pad for ...
A Piaggesi +26 more
core +2 more sources
Therapeutic management of the enzymatic debriding agent Nexobrid® in the burn patient
Indian Journal of Burns, 2018 Enzymatic debridement with Nexobrid® is a recently appeared resource, which allows a selective elimination of burned tissues with one single application, becoming a new resource in the therapeutic arsenal of the burn surgeon.
Enrique Salmeron-Gonzalez +4 more
doaj +1 more source
Quality control of a medicinal larval (Lucilia sericata) debridement device based on released gelatinase activity [PDF]
, 2017 Lucilia sericata Meigen (Diptera: Calliphoridae) larvae are manufactured worldwide for the treatment of chronic wounds. Published research has confirmed that the primary clinical effect of the product, debridement (the degradation of non-viable wound ...
Abraham +32 more
core +1 more source