Activation of Deoxyribonuclease I by Nicotinamide as a New Strategy to Attenuate Tetracycline-Resistant Biofilms of Cutibacterium acnes [PDF]
Pharmaceutics, 2021 Biofilms of Cutibacterium (C.) acnes (formerly Propionibacterium acnes) are responsible for the persistence and antibiotic resistance of acne vulgaris. In addition to the standard treatments for acne vulgaris, a common adjunctive treatment is the topical
Yi-Hsien Shih +5 more
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Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu +9 more
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Effects of exogenous deoxyribonuclease I in collagen antibody-induced arthritis [PDF]
Journal of InflammationBackground Rheumatoid arthritis (RA) is associated with a high concentration of extracellular DNA (ecDNA). This could be a consequence of the inflammation, but the ecDNA could also be involved in the unknown etiopathogenesis of RA.
Kristína Macáková +9 more
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Gene therapy enhances deoxyribonuclease I treatment in antimyeloperoxidase glomerulonephritis [PDF]
JCI InsightExtracellular DNA (ecDNA) released from injured and dying cells powerfully induces injurious inflammation. In this study we define the role of ecDNA in systemic vasculitis affecting the kidney, using human kidney biopsies and murine models of ...
Anne Cao Le +13 more
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Use of Recombinant Human Deoxyribonuclease I in Primary Ciliary Dyskinesia Bronchiectasis—A Real Life Pilot Study [PDF]
Medical SciencesIntroduction: Recombinant human deoxyribonuclease I (rhDNase) cleaves DNA in mucus, facilitating increased mucociliary clearance of purulent sputum. In cystic fibrosis (CF), rhDNase improves pulmonary function and decreases exacerbations.
Moshe Heching +4 more
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Tumor-Derived Exosomal Fatty Acids Reprogram Neutrophils to Drive Neutrophil Extracellular Traps Formation and Lung Cancer Progression [PDF]
ResearchTumor-infiltrating neutrophils are increasingly recognized as key drivers of cancer progression, but the mechanisms that govern their protumoral reprogramming remain elusive.
Lulu Han +12 more
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Enhancing implant surfaces: mechanical stability and cytocompatibility of DNase I coatings deposited by alternating current electrophoretic deposition [PDF]
Frontiers in Bioengineering and BiotechnologyDeoxyribonuclease I (DNase I) is an enzyme that hydrolyzes the phosphodiester bonds in the DNA backbone, enabling efficient DNA degradation. This activity is particularly relevant for degrading extracellular DNA (eDNA), a key structural component of the ...
Merve Kübra Aktan +7 more
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Revista Paulista de Pediatria, 2021 Objective: Dornase alfa (rhDNase) reduces the viscosity of purulent sputum in the lungs. The use in patients with cystic fibrosis (CF) is proven. However, the evidence of its applicability to other conditions is limited.
Daniel Meireles +6 more
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A Molecular Dynamics Simulation Study of the Arg206Cys Variant in DNASE1L3 Enzyme
Biology and Life Sciences Forum, 2022 Genome-wide association studies (GWAS) have identified that one of the autoimmune disease-associated loci, predisposing for the development of Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and Systemic Sclerosis (SSc), is the rs35677470 ...
Manio Skarlatou +3 more
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Microorganisms, 2023 Pectobacterium carotovorum subsp. carotovorum (Pcc) is known to produce different types of bacteriocins, active protein substances that inhibit or kill related strains and are known to be induced by several factors. In this paper, we report the discovery,
Huang-Pin Wu +4 more
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