Results 11 to 20 of about 159,619 (187)

The inhibition of deoxyribonuclease I by hydroxybiphenyls [PDF]

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract DNA extracted with certain commercial brands of phenol is resistant to hydrolysis by the endonuclease deoxyribonuclease I, while DNA extracted with other brands, or prepared by NaCl extraction, is susceptible to hydrolysis. The agent responsible for inhibition has been shown to be an oxidation product produced in some phenols.
Gottesfeld, J M, Adams, N H, El-Badry, A M, Moses, V, Calvin, M   +4 more
openaire   +3 more sources

Synthesis and DNase I Inhibitory Properties of New Squaramides

Molecules, 2023
Three new monosquaramides (3a–c) were synthesized, characterized by IR, NMR and X-ray, and evaluated for inhibitory activity against deoxyribonuclease I (DNase I) and xanthine oxidase (XO) in vitro. The target compounds inhibited DNase I with IC50 values
Nina Ruseva, Hristina Sbirkova-Dimitrova, Mariyana Atanasova, Ana Marković, Žaklina Šmelcerović, Andrija Šmelcerović, Adriana Bakalova, Emiliya Cherneva   +7 more
doaj   +1 more source

Immunothrombosis and Complement Activation Contribute to Disease Severity and Adverse Outcome in COVID-19

Journal of Innate Immunity, 2023
Severe COVID-19 is characterized by systemic inflammation and multiple organ dysfunction syndrome (MODS). Arterial and venous thrombosis are involved in the pathogenesis of MODS and fatality in COVID-19.
Tiphaine Ruggeri, Yasmin De Wit, Noëlia Schärz, Gerard van Mierlo, Anne Angelillo-Scherrer, Justine Brodard, Joerg C. Schefold, Cédric Hirzel, Ilse Jongerius, Sacha Zeerleder   +9 more
doaj   +1 more source

Deoxyribonuclease Treatment Improves the Homogeneity of Single-Stranded DNA Preparations

BioTechniques, 1997
The isolation of single-stranded (ss) phagemid DNA using standard protocols often results in impure preparations, which contain undesirable quantities of chromosomal and/or double-stranded (ds) phagemid DNA.
T.K. Aliev, A.A. Panina, V.G. Korobko, S.D. Varfolomeyev   +3 more
doaj   +1 more source

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Cisplatin Nephrotoxicity Is Mediated by Deoxyribonuclease I [PDF]

Journal of the American Society of Nephrology, 2005
Cisplatin is commonly used for chemotherapy in a wide variety of tumors; however, its use is limited by kidney toxicity. Although the exact mechanism of cisplatin-induced nephrotoxicity is not understood, several studies showed that it is associated with DNA fragmentation induced by an unknown endonuclease.
Alexei G, Basnakian, Eugene O, Apostolov, Xiaoyan, Yin, Markus, Napirei, Hans Georg, Mannherz, Sudhir V, Shah   +5 more
openaire   +2 more sources

Extraction and purification of bovine pancreatic Deoxyribonuclease I

مجلة مركز بحوث التقنيات الاحيائية, 2010
Samples of bovine pancreatic and calf thymus glands were collected from local slaughterers to extract deoxyribonuclease I enzyme (DNase I) and DNA respectively.
Baidaa S. Hermiz, Ghazi M. Aziz, Abdel kareem A. Alkazaz   +2 more
doaj   +1 more source

Self‐Propelled Proteomotors with Active Cell‐Free mtDNA Clearance for Enhanced Therapy of Sepsis‐Associated Acute Lung Injury

Advanced Science, 2023
Acute lung injury (ALI) is a frequent and serious complication of sepsis with limited therapeutic options. Gaining insights into the inflammatory dysregulation that causes sepsis‐associated ALI can help develop new therapeutic strategies.
Weichang Huang, Lihong Wen, Hao Tian, Jiamiao Jiang, Meihuan Liu, Yicheng Ye, Junbin Gao, Ruotian Zhang, Fei Wang, Huaan Li, Lihan Shen, Fei Peng, Yingfeng Tu   +12 more
doaj   +1 more source

Chronic endometritis. Local prooxidant, antioxidant and immunometabolic disorders. An open-label, prospective, randomized study [PDF]

Гинекология
Aim. To determine local features of lipoperoxidation processes, antioxidant defense, state of matrix metalloproteinases in chronic endometritis. Materials and methods.
Oksana A. Gizinger, Yury A. Sorokin, Viktor E. Radzinskiy   +2 more
doaj   +1 more source