Results 101 to 110 of about 3,151,868 (313)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Enzyme-Catalysis

, 2019
As a pioneer of the enzymes manufacturer industry, Creative Enzymes is known as its specialization and consolidates its leader's position in this field gradually since the year founded by always taking initiative in this field.
Iva Colter (6713138)
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation [PDF]

, 2017
Hydroalkoxylation is a powerful and efficient method of forming C–O bonds and cyclic ethers in synthetic chemistry. In studying the biosynthesis of the fungal natural product herque­inone, we identified an enzyme that can perform an intra­molecular ...
Yang Hai (830201), K. N. Houk, Duan, Abing, Shu-Shan Gao, Yang Hai, Hai, Yang, Barber, Joyann S, Joyann S. Barber, Joyann S. Barber (3804121), K. N. Houk (1247004), Neil K. Garg (1307112), Yi Tang (55726), Neil K. Garg, Garcia-Borràs, Marc, Houk, KN, Yi Tang, Abing Duan (1867492), Marc Garcia-Borràs, Gao, Shu-Shan, Garg, Neil K, Marc Garcia-Borràs (1530844), Shu-Shan Gao (1823578), Abing Duan, Tang, Yi   +23 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Tests of predictions made by the Equilibrium Model for the effect of temperature on enzyme activity [PDF]

, 2008
The Classical Model describing the effects of temperature on enzyme activity consists of two processes: the catalytic reaction defined by ΔG cat and irreversible inactivation defined by ΔG inact, this model however, does not account for the observed ...
Oudshoorn, Matthew Leslie
core  

Comparative transcriptome analysis reveals key genes associated with meiotic stability and high seed setting rate in tetraploid rice

BMC Plant Biology
Background Polyploid rice has a high yield potential and excellent nutritional quality. The development of polyploid rice remained critically limited for several decades due to low seed setting rate until the successful breeding of polyploid meiosis ...
Pincang Lv, Man Wang, Rongjie Qiu, Chang Yao, Meng Fang, Yuandong Xing, Xianhua Zhang, Yuchi He, Detian Cai, Zhaojian Song   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]

, 2008
The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Steffen Kutter, König, Stephan, Kutter, Steffen, Manfred Weiss, Golbik, Ralph, Michael Spinka, Stephan König, Georg Wille, Ralph Golbik, Spinka, Michael, Weiss, Manfred S., Wille, Georg   +11 more
core  

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source