Results 91 to 100 of about 6,529,404 (392)

Proton tunneling in hydrogen bonds and its implications in an induced-fit model of enzyme catalysis

, 2018
The role of proton tunneling in biological catalysis is investigated here within the frameworks of quantum information theory and thermodynamics.
Burnett, Keith, Deliduman, Cemsinan, Farrow, Tristan, Pusuluk, Onur, Vedral, Vlatko   +4 more
core   +1 more source

A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation*

Journal of Biological Chemistry, 2008
Poly(ADP-ribose) polymerase-1 (PARP-1) is a chromatin-associated enzyme with multiple cellular functions, including DNA repair, transcriptional regulation, and cell signaling.
M. Langelier, Kristin M. Servent, E. Rogers, J. Pascal   +3 more
semanticscholar   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela, Emami, Freije, Frenette, Gomis, Hollenberg, Itoh, Jung, Lopez, Ohler, Pampalakis, Ramsay, Ries, Rittenhouse, Ryu, Shaw, Sperl, Takayama, Takayama, Tye, Yoon, Yoon   +21 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Structural basis of the selective activation of enzyme isoforms: Allosteric response to activators of β1- and β2-containing AMPK complexes

Computational and Structural Biotechnology Journal, 2021
AMP-activated protein kinase (AMPK) is a key energy sensor regulating the cell metabolism in response to energy supply and demand. The evolutionary adaptation of AMPK to different tissues is accomplished through the expression of distinct isoforms that ...
Elnaz Aledavood, Alessia Forte, Carolina Estarellas, F. Javier Luque   +3 more
doaj  

Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets. [PDF]

PLoS ONE, 2010
As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme.
Emilia Heimann, Helena A Jones, Svante Resjö, Vincent C Manganiello, Lena Stenson, Eva Degerman   +5 more
doaj   +1 more source

Vicinal glutamates are better phosphomimetics: Phosphorylation is required for allosteric activation of guanylyl cyclase-A

Frontiers in Molecular Neuroscience, 2022
Multisite phosphorylation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, is required for receptor activation by natriuretic peptides (NPs) because alanine substitutions for the first four GC-A phosphorylation sites produce an enzyme that cannot
Neil M. Otto, Lincoln R. Potter
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas. [PDF]

PLoS ONE, 2016
Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a fluorogenic substrate.
Tasha B Toro, Subramanya Pingali, Thao P Nguyen, Destane S Garrett, Kyra A Dodson, Kyara A Nichols, Rashad A Haynes, Florastina Payton-Stewart, Terry J Watt   +8 more
doaj   +1 more source