Results 81 to 90 of about 6,455,122 (370)

Ack1: activation and regulation by allostery. [PDF]

PLoS ONE, 2013
The non-receptor tyrosine kinase Ack1 belongs to a unique multi-domain protein kinase family, Ack. Ack is the only family of SH3 domain containing kinases to have an SH3 domain following the kinase domain; others have their SH3 domains preceding the ...
Ketan S Gajiwala, Karen Maegley, RoseAnn Ferre, You-Ai He, Xiu Yu   +4 more
doaj   +1 more source

Expression and modulation of an NADPH oxidase in mammalian astrocytes [PDF]

, 2005
Amyloid β peptides generate oxidative stress in hippocampal astrocytes through a mechanism sensitive to inhibitors of the NADPH oxidase [diphenylene iodonium (DPI) and apocynin].
Abramov, A.Y., Canevari, L., Duchen, M.R., Hothersall, J., Jacobson, J., Wientjes, F.   +5 more
core   +1 more source

A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation*

Journal of Biological Chemistry, 2008
Poly(ADP-ribose) polymerase-1 (PARP-1) is a chromatin-associated enzyme with multiple cellular functions, including DNA repair, transcriptional regulation, and cell signaling.
M. Langelier, Kristin M. Servent, E. Rogers, J. Pascal   +3 more
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas. [PDF]

PLoS ONE, 2016
Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a fluorogenic substrate.
Tasha B Toro, Subramanya Pingali, Thao P Nguyen, Destane S Garrett, Kyra A Dodson, Kyara A Nichols, Rashad A Haynes, Florastina Payton-Stewart, Terry J Watt   +8 more
doaj   +1 more source

Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]

, 2014
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Airaksinen, Annabel Borg, Arighi, Artim, Chan, Chen, Chen, Chen, Coulpier, Cutillas, DiNitto, Endres, Furdui, Gibelin, Hubbard, Hubbard, Iván Plaza-Menacho, Judith Murray-Rust, Karin Barnouin, Kawamoto, Kerry Goodman, Knowles, Lew, Lougheed, McTigue, Mologni, Neil Q. McDonald, Phillip Knowles, Plaza Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Rubén J. Martínez-Torres, Santoro, Stamos, Steen, Stephane Mouilleron, Wiesner, Yun, Zhang   +40 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Vicinal glutamates are better phosphomimetics: Phosphorylation is required for allosteric activation of guanylyl cyclase-A

Frontiers in Molecular Neuroscience, 2022
Multisite phosphorylation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, is required for receptor activation by natriuretic peptides (NPs) because alanine substitutions for the first four GC-A phosphorylation sites produce an enzyme that cannot
Neil M. Otto, Lincoln R. Potter
doaj   +1 more source

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Redox Biology, 2014
Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Csaba Hegedűs, László Virág
doaj   +1 more source