Results 111 to 120 of about 1,754,066 (244)

Aggregation of Phosphates Enhances Enzyme Activity in Aqueous Solution. [PDF]

Chemphyschem
Bajpayee S, Murugan V, Price WS, Rana S, Beves JE.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors. [PDF]

Signal Transduct Target Ther
Rai C, Ruan H, Li X, Li W, Jeong HH, Song C, Liu P, Chang Y, Fang H, Kumar S U, Sun Y, You MJ, Guan D, Liu Z, Han L, Hou X, Sun Z.   +16 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Selective Alterations of Thiol Redox Homeostasis and Antioxidant Enzyme Activity in Advanced Atherosclerosis. [PDF]

Int J Mol Sci
Marić R, Ćurčić B, Vidonja Uzelac T, Grahovac T, Oreščanin Dušić Z, Radanović S, Batinić-Škipina D, Drakul D.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unleashing the power of visible-near infrared spectroscopy: predicting Golden Delicious apple enzyme activity. [PDF]

J Sci Food Agric
Mesri Gundoshmian T, Razavi MS, Akbari R, Tahmasebi M, Locatelli I, Grassi S.   +5 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

ADA2 genotype and enzyme activity may predict vasculitic or hematologic DADA2 phenotype. [PDF]

J Hum Immun
Peters P, Schepp J, Albert MH, von Bernuth H, Blank N, Brunner J, Dückers G, Ehlers L, Farmand S, Föll D, Förster-Waldl E, Gburek-Augustat J, Ghosh S, Göschl L, Hömberg M, Hönig M, Kallinich T, Klemann C, Klingel L, Kontny U, Kuhn LM, Lamprecht P, Lehmberg K, Meyer-Bahlburg A, Müller I, Nathrath M, Niehues T, Oommen PT, Pachlopnik Schmid J, Prader S, Puzik A, Renella R, Schulz A, Skrabl-Baumgartner A, Starke S, Tarrant TK, Hershfield M, Grimbacher B, Hauck F.   +38 more
europepmc   +1 more source